Preparation of PCL/(+)-catechin/gelatin film for wound healing using air-jet spinning
Preparation of PCL/(+)-catechin/gelatin film for wound healing using air-jet spinning
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DOI：
10.1016/j.apsusc.2019.145033
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发表时间：
2020-04-15
影响因子：
6.7
通讯作者：
Lee, Donghyun
中科院分区：
文献类型：
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作者：
Baek, Seungho;Park, Heekyung;Lee, Donghyun
喷气纺丝已被用于制造纳米级微直径纤维，在伤口治疗贴片、纱布、移植支架等医疗产品中得到广泛应用。特别是伤口从浅到深不等，基本上伤口容易受到外界有害因素的感染。因此，阻止有害因素进入创面是非常重要的。此外，伤口部位具有高水平的氧化应激，因此建议使用抗氧化剂作为伤口治疗的良好解决方案。我们将具有良好生物相容性的明胶、具有高抗氧化活性的儿茶素、以及将聚己内酯纺丝在儿茶素和明胶薄膜上制成双层结构的伤口愈合剂。这种结构阻断了有害的外部因素，是有效伤口治疗的候选材料。
Air-jet spinning has been used to fabricate fibers with nano-micro diameters and is widely applied in medical products such as wound treatment patches, gauze, and graft scaffolds. In particular, wounds vary from light to deep, and basically the wound is vulnerable to infection by external harmful factors. Therefore, blocking harmful factors from entering the wound area is very important. In addition, the wound site has high levels of oxidative stress, and thus the use of antioxidants is suggested as a good solution for wound treatment. We developed wound healing agents using gelatin, which shows excellent biocompatibility, catechin, which has high antioxidant activity, and polycaprolactone, which was spun on catechin and gelatin films, to produce a double layered structure using air-jet spinning. This structure blocked harmful external factors and is a candidate for efficient wound treatment.