Single bismuth tungstate nanosheets for simultaneous chemo-, photothermal, and photodynamic therapies mediated by near-infrared light
Single bismuth tungstate nanosheets for simultaneous chemo-, photothermal, and photodynamic therapies mediated by near-infrared light
复制标题
用于近红外光介导的同步化疗、光热和光动力疗法的单一钨酸铋纳米片
DOI：
10.1016/j.cej.2018.06.170
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发表时间：
2018-11-01
影响因子：
15.1
通讯作者：
Lin, Jun
中科院分区：
文献类型：
--
作者：
Feng, Lili;Yang, Dan;Lin, Jun
与单一治疗模式相比，协同治疗提供了许多优点，例如高效率和低复发风险，而目前治疗剂的采用受到未解决的问题的极大阻碍，包括药物负载能力差和治疗效果不满意。本文提出并制备了一种多功能纳米治疗剂，它由聚乙二醇化和DOX负载的钨酸铋纳米片（Bi 2 WO 6-DOX-PEG NSs）组成。Bi 2 WO 6纳米棒不仅具有良好的载药量（81.3wt%），而且在低功率密度（0.5Wcm-2）的高穿透近红外（NIR）光照射下，能产生活性氧（ROS）和高热效应（36.5%的传热系数）。体内外实验表明，Bi 2 WO 6-DOX-PEG纳米粒具有良好的光稳定性和良好的CT成像效果，且全身毒性小。体内实验结果也显示出Bi 2 WO 6-DOX-PEG的肿瘤消融性能明显高于任何单一模式治疗，这源于近红外激光触发的协同效应。作为首次将Bi 2 WO 6纳米材料作为光疗剂的实验研究，我们的研究结果为这种二维纳米材料在生物医学领域的应用奠定了基础。
Synergistic treatment provides many advantages such as high efficiency and low risk of recurrence compared to single mode of therapy, while the current adoption of therapeutic agents have been greatly stifled by unresolved concerns including poor drug loading capacity and dissatisfactory therapeutic effect. Here we proposed and fabricated a multifunctional nanotheranostic agent, which consists of PEGylated and DOX-loaded bismuth tungstate nanosheets (abbreviated as Bi2WO6-DOX-PEG NSs). The Bi2WO6 NSs not only possess excellent drug loading capacity (81.3 wt%), but also can generate reactive oxygen species (ROS) and high hyperthermia effect (36.5% heat transfer coefficient) when irradiated by high penetrated near-infrared (NIR) light with low power density (0.5 W cm(-2)). The in vitro and in vivo experiments show that the Bi2WO6-DOX-PEG NSs have negligible systemic toxicity, good photostability, and excellent computer tomography (CT) imaging effect. In vivo results also exhibit obviously higher tumor ablation performance of Bi2WO6-DOX-PEG than any single-modal therapy, which is derived from NIR laser triggered synergistic effect. As the first demonstration of Bi2WO6 NSs as phototherapy agent, our finding may pave the way for the application of this kind of two-dimensional (2D) nanomaterials in biomedical field.