Rising prevalence of allergy to peanut in children: Data from 2 sequential cohorts
Rising prevalence of allergy to peanut in children: Data from 2 sequential cohorts
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DOI：
10.1067/mai.2002.128802
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发表时间：
2002-11-01
影响因子：
14.2
通讯作者：
Arshad, SH
中科院分区：
文献类型：
--
作者：
Grundy, J;Matthews, S;Arshad, SH
背景：对花生过敏很常见。然而，目前尚不清楚对花生的过敏和临床过敏的患病率是否正在增加。目的：我们试图确定同一地理区域相隔 6 年的 2 个连续队列中幼儿期花生过敏和反应性患病率的变化。方法：在 1994 年 9 月 1 日至 1996 年 8 月 31 日期间出生、居住在怀特岛的 2878 名儿童中，1273 名填写了问卷， 1246 名儿童在 3 至 4 岁时接受了皮肤点刺测试。那些对花生皮肤点刺试验呈阳性反应的人会接受口服花生挑战，除非有立即全身反应的历史。将这些数据与来自同一地理区域的 1989 年出生的先前队列的花生致敏和临床过敏信息进行比较。结果：报告的花生过敏增加了 2 倍（0.5% [6/1218] 至 1.0% [13/1273]），但差异不显着（P = .2）。花生过敏率增加了 3 倍，1994 年至 1996 年间，1246 名儿童中有 41 名（3.3%）对花生过敏，而 6 年前，981 名儿童中有 11 名（1.1%）过敏（P = .001）。在本研究中的 41 名过敏儿童中，10 名报告对花生有令人信服的临床反应，8 名有阳性口服激发结果，花生过敏的总体估计为 1.5% (18/1246)。结论：1989 年、1994 年至 1996 年间，对花生的过敏有所增加。报告的花生过敏增加趋势强烈，但统计上不显着。
Background: Allergy to peanut is common. However, it is not known whether the prevalence of sensitization and clinical allergy to peanut is increasing.Objective: We sought to determine any change in the prevalence of peanut sensitization and reactivity in early childhood in 2 sequential cohorts in the same geographic area 6 years apart.Methods: Of 2878 children born between September 1, 1994, and August 31, 1996, living on the Isle of Wight, 1273 completed questionnaires, and 1246 had skin prick tests at the age of 3 to 4 years. Those with positive skin prick test responses to peanut were subjected to oral peanut challenges, unless there was a history of immediate systemic reaction. These data were compared with information on sensitization and clinical allergy to peanut available from a previous cohort born in 1989 in the same geographic area.Results: There was a 2-fold increase in reported peanut allergy (0.5% [6/1218] to 1.0% [13/1273]), but the difference was nonsignificant (P = .2). Peanut sensitization increased 3-fold, with 41 (3.3%) of 1246 children sensitized in 1994 to 1996 compared with 11 (1.1%) of 981 sensitized 6 years ago (P = .001). Of 41 sensitized children in the current study, 10 reported a convincing clinical reaction to peanut, and 8 had positive oral challenge results, giving an overall estimate of peanut allergy of 1.5% (18/1246).Conclusions: Sensitization to peanut had increased between 1989 and 1994 to 1996. There was a strong but statistically nonsignificant trend for increase in reported peanut allergy.