Cutting edge: Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo
Cutting edge: Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo
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DOI：
10.4049/jimmunol.166.3.1439
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发表时间：
2001-02-01
影响因子：
4.4
通讯作者：
Brocker, T
中科院分区：
文献类型：
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作者：
Kurts, C;Cannarile, M;Brocker, T
交叉提呈机制使专职APC能够诱导CD8 T细胞介导的针对外源性Ag的免疫应答。通过这种机制，APC可以诱导针对感染性病原体的免疫或针对驻留在淋巴外位置的自身Ag的耐受。在这一领域的一个悬而未决的问题涉及交叉呈递APC的身份。所有主要类别的专职APC，特别是树突状细胞、巨噬细胞和B细胞，先前已显示能够在体外交叉呈递Ag。在本研究中，我们已经创建了转基因小鼠，其中MHC I类分子的表达被选择性地驱动在树突状细胞，并提供直接的体内证据表明，树突状细胞足以交叉呈递外源性自身抗原，并诱导抗原特异性细胞分裂的CD8阳性T细胞。
The mechanism of cross-presentation enables professional APCs to induce CD8 T cell-mediated immune responses against exogenous Ags. Through this mechanism, APCs can induce either immunity against infectious pathogens or tolerance against self-Ag residing in extralymphatic locations. An unanswered question in this field concerns the identity of the cross-presenting APC. All major classes of professional APCs, particularly dendritic cells, macrophages, and B cells, have previously been shown to be able to cross-present Ags in vitro. In the present study, we have created transgenic mice where MHC class I expression is driven selectively in dendritic cells and provide direct in vivo evidence that dendritic cells are sufficient to cross-present exogenous self-Ags and induce Ag-specific cell division of CD8-positive T cells.