Differential codon usage: a safeguard against inappropriate expression of specialized genes?
Differential codon usage: a safeguard against inappropriate expression of specialized genes?
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差异密码子使用：防止特殊基因不当表达的保障？
DOI：
10.1016/0014-5793(95)00185-c
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发表时间：
1995
期刊：
影响因子：
3.5
通讯作者：
SaierJr,MH
中科院分区：
文献类型：
--
作者：
SaierJr,MH
最近的研究表明，稀有密码子有时用于调节细菌中专门的基因表达。此外，某些 tRNA 的细胞水平可能会随着生长条件而波动。有证据表明这些机制在红细菌属的光合作用、梭菌属的溶剂生成、链霉菌属的孢子形成和大肠杆菌属的菌毛相变化中的控制。大肠杆菌总结。有人建议，这种机制将被证明适用于控制许多额外的专门功能，并且目前可以使用用于测试这种可能性的经验工具。
Recent work has suggested that rare codons are sometimes used for the regulation of specialized gene expression in bacteria. Moreover, the cellular levels of certain tRNAs may fluctuate with growth conditions. Evidence implicating such mechanisms in the control of photosynthesis inRhodobacter, solventogenesis inClostridium, sporulation inStreptomyces, and fimbrial phase variation inE. coliis summarized. It is suggested that such mechanisms will prove applicable to the control of numerous additional specialized functions, and that the empirical tools for testing this possibility are currently available.