Clinical significance of microsatellite instability in the inflamed mucosa for the prediction of colonic neoplasms in patients with ulcerative colitis
Clinical significance of microsatellite instability in the inflamed mucosa for the prediction of colonic neoplasms in patients with ulcerative colitis
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DOI：
10.1111/j.1440-1746.2005.03803.x
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发表时间：
2005-05
影响因子：
4.1
通讯作者：
T. Tahara;N. Inoue;T. Hisamatsu;K. Kashiwagi;H. Takaishi;T. Kanai;Mamoru Watanabe;H. Ishii;T. Hibi
中科院分区：
文献类型：
--
作者：
T. Tahara;N. Inoue;T. Hisamatsu;K. Kashiwagi;H. Takaishi;T. Kanai;Mamoru Watanabe;H. Ishii;T. Hibi
背景和目的：尽管对溃疡性结肠炎（UC）相关肿瘤的分子机制已经研究多年，但对这些机制的理解仍然不完整，并且尚未建立溃疡性结肠炎患者结肠肿瘤发展的良好可预测标志物。本研究的目的是评估微卫星不稳定性（MSI）是否有助于UC患者结肠肿瘤的发展。
Background and Aim: Although molecular mechanisms underlying ulcerative colitis (UC)‐associated neoplasms have been studied for years, understanding of these mechanisms remains incomplete and no good predictable marker for development of colonic neoplasms in patients with UC has been established. The aim of this study was to assess if microsatellite instability (MSI) contributes to the development of colonic neoplasms in patients with UC.