Mechanisms of membrane transport of folates into cells and across epithelia.
Mechanisms of membrane transport of folates into cells and across epithelia.
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DOI：
10.1146/annurev-nutr-072610-145133
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发表时间：
2011-08-21
影响因子：
8.9
通讯作者：
Goldman ID
中科院分区：
文献类型：
--
作者：
Zhao R;Diop-Bove N;Visentin M;Goldman ID
直到最近，叶酸进入细胞和穿过上皮的转运主要是在对叶酸具有高亲和力和特异性的两种转运蛋白，还原叶酸载体和叶酸受体的背景下解释的。然而，在pH依赖性和底物特异性方面，这些转运蛋白的性质与许多组织中叶酸转运的特征之间存在差异，最显著的是叶酸的肠吸收。随着最近克隆的质子偶联叶酸转运蛋白（PCFT）和证明，这种转运蛋白是突变的遗传性叶酸吸收不良，常染色体隐性遗传病，这种低pH值的运输活动的分子基础，现在被理解。本文综述了PCFT的性质，并简要介绍了其他两个叶酸特异性转运蛋白沿着其他促进和ATP结合盒（ABC）转运蛋白与叶酸转运活动。被认为是这些转运蛋白的叶酸跨上皮细胞的矢量运输的作用。
Until recently, the transport of folates into cells and across epithelia has been interpreted primarily within the context of two transporters with high affinity and specificity for folates, the reduced folate carrier and the folate receptors. However, there were discrepancies between the properties of these transporters and characteristics of folate transport in many tissues, most notably the intestinal absorption of folates, in terms of pH dependency and substrate specificity. With the recent cloning of the proton-coupled folate transporter (PCFT) and the demonstration that this transporter is mutated in hereditary folate malabsorption, an autosomal recessive disorder, the molecular basis for this low-pH transport activity is now understood. This review focuses on the properties of PCFT and briefly addresses the two other folate-specific transporters along with other facilitative and ATP-binding cassette (ABC) transporters with folate transport activities. The role of these transporters in the vectorial transport of folates across epithelia is considered.
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DOI：
10.1124/jpet.106.104364
发表时间：
2006-08-01
影响因子：
3.5
作者：
Badagnani, Ilaria;Castro, Richard A.;Giacomini, Kathleen M.
通讯作者：
Giacomini, Kathleen M.
影响因子：
5.8
作者：
Assaraf, YG;Sierra, EE;Goldman, ID
通讯作者：
Goldman, ID
影响因子：
13.6
作者：
Birn, H;Spiegelstein, O;Finnell, RH
通讯作者：
Finnell, RH
影响因子：
3.6
作者：
Cha, SH;Sekine, T;Endou, H
通讯作者：
Endou, H
影响因子：
5.7
作者：
Chattopadhyay, S;Zhao, RB;Goldman, DI
通讯作者：
Goldman, DI