Variation in total and specific IgE:: Effects of ethnicity and socioeconomic status
Variation in total and specific IgE:: Effects of ethnicity and socioeconomic status
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DOI：
10.1016/j.jaci.2004.12.1138
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发表时间：
2005-04-01
影响因子：
14.2
通讯作者：
Gold, DR
中科院分区：
文献类型：
--
作者：
Litonjua, AA;Celedón, JC;Gold, DR
背景：哮喘在少数民族和弱势群体中很常见，而哮喘以外的特应性疾病似乎不太常见。目前还不清楚是否同样适用于客观的过敏标记物。目的：确定哮喘，特应性疾病和特异性致敏与种族和社会经济因素的关系。方法：我们分析了882名妇女的总IgE和特异性IgE（577名白色，169名黑人和136名西班牙裔）在马萨诸塞州波士顿的一家大型三级医院分娩，并筛选参与家庭和出生队列研究的患者。从筛选问卷中获得人种/种族和其他特征。地理编码，和3个基于人口普查的地理区域的社会经济变量来自1990年美国人口普查的信息块组。结果：黑人和西班牙裔妇女更有可能来自低社会经济指标的地区，更有可能比白色妇女哮喘。然而，这些女性比她们的白色同伴更不容易患花粉热和湿疹。与白色妇女相比，黑人妇女有较高的平均总IgE水平，有更大比例的室内，室外和真菌过敏原的敏感性，并有超过两倍的可能被致敏>= 3 aeroallergens.Conclusion：种族/民族的差异，特应性疾病可能代表要么诊断不足或漏报，并建议过敏试验可能在某些人群中使用不足。总IgE水平和特异性过敏原致敏的差异可能是与社会经济不利因素相关的暴露之间复杂相互作用的结果。
Background: Asthma is common in minority and disadvantaged populations, whereas atopic disorders other than asthma appear to be less prevalent. It is unclear whether the same holds true for objective markers of sensitization.Objective: To determine the association of asthma, atopic disorders, and specific sensitization with race and socioeconomic factors.Methods: We analyzed total and specific IgE among 882 women (577 white, 169 black, and 136 Hispanic) who delivered a child at a large tertiary hospital in Boston, Mass, and who were screened for participation in a family and birth cohort study. Race/ethnicity and other characteristics were obtained from screening questionnaires. Addresses were geocoded, and 3 census-based geographic area socioeconomic variables were derived from block group information from the 1990 US Census.Results: Black and Hispanic women were more likely to come from areas with low socioeconomic indicators and were more likely to have asthma than white women. However, these women were less likely to have hay fever and eczema than their white counterparts. Compared with white women, black women had higher mean total IgE levels; had greater proportions of sensitization to indoor, outdoor, and fungal allergens; and were more than twice as likely to be sensitized to >= 3 aeroallergens.Conclusion: The racial/ethnic disparities in atopic disorders may represent either underdiagnosis or underreporting and suggest that allergy testing may be underused in some populations. Differences in total IgE levels and specific allergen sensitization are likely a result of the complex interplay between exposures associated with socioeconomic disadvantage.