A Novel Aging Phenotype of Slow Gait, Impaired Executive Function, and Depressive Symptoms: Relationship to Blood Pressure and Other Cardiovascular Risks
A Novel Aging Phenotype of Slow Gait, Impaired Executive Function, and Depressive Symptoms: Relationship to Blood Pressure and Other Cardiovascular Risks
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DOI：
10.1093/gerona/glp075
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发表时间：
2009-09-01
影响因子：
5.1
通讯作者：
Lipsitz, Lewis A.
中科院分区：
文献类型：
--
作者：
Hajjar, Ihab;Yang, Frances;Lipsitz, Lewis A.
评估背景。我们的目标是调查一组同时有认知障碍的非痴呆老年人的存在。机动性。和心情。并检查作为这一群体的一员与高血压和其他心血管疾病之间的联系。保持平衡。独立生活，智慧。而波士顿老年人的Zest研究是一项正在进行的针对社区居民个人的前瞻性观察研究。我们分析了在基线(N=580)收集的横断面数据。平均年龄77.8岁，所占比例为女性。14%的非裔美国人，平均为27.2)。利用潜伏期分析。我们调查了老年参与者在执行功能(连线测试B部分[TMT-B])、步速(两个4米步行测试)和抑郁症状(流行病学研究中心抑郁量表[CES-D])方面是否存在损害。我们确定了一组(n=99[17%])TMT-B延长，步速减慢。和高CES-D分数。当我们使用导师MEASURE时，这个群体并不存在。高血压(p=.001糖尿病(1)=.0002)，充血性心力衰竭(p=.006)。卒中(p=0.005)。更高的弗雷明翰心血管风险评分(17=0.0001)与成为这一群体成员的可能性增加相关。在多个协变量调整后，这种与S收缩压和脉压升高以及中风的相关性仍然显著。有一群老年人，他们的执行功能差，步速慢，抑郁症状同时存在。记忆测量没有确定这样的分组。高血压和其他心血管疾病独立地与成为这一群体的成员有关。评估这些领域，是评估老年高血管风险患者的重要组成部分。
Assessing Background. Our objectives were to investigate the existence of a group of nondemented elderly individuals who simultaneously have impairments in cognition. mobility. and mood. and to examine the association between being a member of this group and elevated blood pressure and other cardiovascular conditions.Methods. The Maintenance of Balance. Independent Living, Intellect. and Zest in the Elderly of Boston Study is an ongoing prospective observational study of community-dwelling individuals. we analyzed the cross-sectional data collected at baseline (N = 580. mean age = 77.8 years, 64% women. 14% African American, mean Mini-Mental State Examination = 27.2). Using latent profile analysis. we investigated the existence Of it group of elderly participants with impairments in executive function (Trail Making Test Part B [TMT-B]), gait speed (two 4-m walk tests), and depressive symptoms (Center for Epidemiological Studies-Depression scale [CES-D]).Results. We identified a group (n = 99 [17%]) with prolonged TMT-B, slow gait speed. and high CES-D scores. This group did not exist when we used a mentor, measure. Hypertension (p = .001 diabetes (1) = .0002), congestive heart failure (p = .006). stroke (p = .005). and higher Framingham cardiovascular risk score (17 = .0001) were associated with an increased likelihood of being a member In this group. This association With elevated S systolic and pulse Pressure, and stroke remained significant after Multiple covariate adjustments.Conclusions. There exists a group Of elderly individuals ill whom poor executive function, slow gait speed, and depressive symptoms Occur simultaneously. Memory measures did not identify Such a grouping. Elevated blood pressure and other cardiovascular diseases are independently associated with being it member of this group. Assessing these domains is, an important part of the evaluation of the elderly patients with high Vascular risk.