Genetic variation in resistance of turkeys to experimental infection with Newcastle disease virus.
Genetic variation in resistance of turkeys to experimental infection with Newcastle disease virus.
复制标题
火鸡对新城疫病毒实验性感染的抵抗力的遗传变异。
DOI：
10.2307/1591749
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发表时间：
1992
期刊：
影响因子：
1.4
通讯作者：
R. A. Patterson
中科院分区：
文献类型：
--
作者：
H. Tsai;Y. Saif;K. Nestor;D. Emmerson;R. A. Patterson
用新城疫病毒（NDV）德克萨斯GB株进行了4个试验，分别对4个遗传系的780只雄性和雌性火鸡进行了攻击。这些火鸡系包括两个随机繁殖的对照系（RBC1和RBC2）， RBC1亚系(E)选择用于增加产蛋量，RBC2亚系(F)选择用于增加16周体重。F系火鸡的死亡率（32.5%）显著高于RBC2系（15.8%）、E系（17.5%）和RBC1系（18.4%）。在每次实验结束时，用酶联免疫吸附试验（ELISA）和血凝抑制试验（HI）检测活禽的NDV抗体。E亚系和RBC1系火鸡的ELISA抗体效价明显低于F亚系和RBC2系。亚型F的HI抗体滴度最高，其次是亚型RBC2、RBC1和亚型e。抗体应答与NDV攻击后的死亡率无明显相关性。
Seven hundred eighty male and female turkeys representing four genetic lines were challenged in four experiments with the Texas GB strain of Newcastle disease virus (NDV). The lines of turkeys included two randombred control lines (RBC1 and RBC2), a subline (E) of RBC1 selected for increased egg production, and a subline (F) of RBC2 selected for increased 16-week body weight. Mortality in turkeys of subline F (32.5%) was significantly higher than that in turkeys of line RBC2 (15.8%), subline E (17.5%), and line RBC1 (18.4%). At the end of each experiment, surviving birds were tested for antibody to NDV using the enzyme-linked immunosorbent assay (ELISA) and hemagglutination-inhibition (HI) test. Turkeys of subline E and line RBC1 had significantly lower ELISA antibody titers than those of subline F and line RBC2. Subline F had the highest HI antibody titers, followed in decreasing order by lines RBC2 and RBC1 and subline E. No apparent correlation was found between antibody response and mortality after NDV challenge.