Fungal commensalism modulated by a dual action phosphate transceptor
Fungal commensalism modulated by a dual action phosphate transceptor
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由双重作用磷酸盐受体调节的真菌共生
DOI：
10.1016/j.celrep.2021.110293
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发表时间：
2022
期刊：
影响因子：
8.8
通讯作者：
Ning-Ning Liu
中科院分区：
文献类型：
--
作者：
Yuanyuan Wang;Jia Zhou;Yun Zou;Xiaoqing Chen;Lin Liu;Wanjun Qi;Xinhua Huang;Changbin Chen;Ning-Ning Liu
真菌在波动的生态位中成功定植宿主需要对多种环境压力做出反应和适应。然而，我们对真菌物种如何在胃肠道（GI）生态系统中茁壮成长的理解，通过将多方面的营养压力与稳态宿主-共生相互作用相结合，仍处于起步阶段。在这里，我们发现磷酸盐受体Pho84的耗尽在多种真菌物种的胃肠道定植中遇到了巨大的成本。从机制上讲，Pho84通过双作用活性增强胃肠道共栖，通过诱导转录调节因子Try4和下游共栖相关转录来协调磷酸盐摄取和TOR激活。因此，Pho84促进白色念珠菌的共生，但这并不转化为增强的致病性。因此，我们的研究揭示了Pho84对真菌共生的特定营养依赖双作用调控途径。
Successful host colonization by fungi in fluctuating niches requires response and adaptation to multiple environmental stresses. However, our understanding about how fungal species thrive in the gastrointestinal (GI) ecosystem by combing multifaceted nutritional stress with respect to homeostatic host-commensal interactions is still in its infancy. Here, we discover that depletion of the phosphate transceptor Pho84 across multiple fungal species encountered a substantial cost in gastrointestinal colonization. Mechanistically, Pho84 enhances the gastrointestinal commensalism via a dual-action activity, coordinating both phosphate uptake and TOR activation by induction of the transcriptional regulator Try4 and downstream commensalism-related transcription. As such, Pho84 promotesCandida albicanscommensalism, but this does not translate into enhanced pathogenicity. Thus, our study uncovers a specific nutrient-dependent dual-action regulatory pathway for Pho84 on fungal commensalism.