Lung function and long term exposure to air pollutants in Switzerland
Lung function and long term exposure to air pollutants in Switzerland
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DOI：
10.1164/ajrccm.155.1.9001300
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发表时间：
1997-01-01
影响因子：
24.7
通讯作者：
Zemp, E
中科院分区：
文献类型：
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作者：
AckermannLiebrich, U;Leuenberger, P;Zemp, E
长期暴露于空气污染物的影响进行了研究，在一个横截面的人口为基础的样本的成年人（年龄18至60岁; n = 9,651）居住在瑞士的八个不同地区。标准化的医学检查包括问卷调查、肺功能检查、皮肤点刺试验和呼气末CO浓度。测试了空气污染物年平均值对FVC和FEV（1）的影响（控制年龄和年龄平方、性别、身高、体重、教育水平、国籍和工作场所暴露）。分别对健康的从不吸烟者、戒烟者（控制包年）、当前吸烟者（控制每天吸烟量和包年吸烟量）和整个人群进行分析。在所有亚组和总人群中，NO2、SO2和< 10 μ m的颗粒物（PM（10））对FVC和FEV（1）的影响显著且一致，PM（10）显示出最一致的影响，每10 μ g/m3 FVC变化3.4%。臭氧的结果不太一致。特应性并不影响这种关系。研究区域数量有限，污染物之间的相互关联性很高，因此难以评估单一污染物的影响。我们的结论是，在这项研究中，来自化石燃料燃烧的空气污染，这是瑞士空气污染的主要来源，SO2 NO2和PM（10），与肺功能参数的下降有关。
The effect of long-term exposure to air pollutants was studied in a cross-sectional population-based sample of adults (aged 18 to 60 yr; n = 9,651) residing in eight different areas in Switzerland. Standardized medical examination included questionnaire data, lung function tests, skin-prick testing, and end-expiratory CO concentration. The impact of annual means of air pollutants on FVC and FEV(1) was tested (controlling for age and age squared, sex, height, weight, educational level, nationality, and workplace exposure). Analyses were done separately for healthy never-smokers, ex-smokers (controlling for pack-yr), for current smokers (controlling for cigarettes per day and pack-yr smoked), and for the whole population. Significant and consistent effects on FVC and FEV(1) were found for NO2 SO2 and particulate matter < 10 mu m (PM(10)) in all subgroups and in the total population, with PM(10) showing the most consistent effect of a 3.4% change in FVC per 10 mu g/m(3). Results for ozone were less consistent. Atopy did not influence this relationship. The limited number of study areas and high intercorrelation between the pollutants make it difficult to assess the effect of one single pollutant. Our conclusion is that air pollution from fossil fuel combustion, which is the main source of air pollution with SO2 NO2 and PM(10) in Switzerland, is associated with decrements in lung function parameters in this study.