Effect of acyclovir on HIV-1 set point among herpes simplex virus type 2-seropositive persons during early HIV-1 infection.
Effect of acyclovir on HIV-1 set point among herpes simplex virus type 2-seropositive persons during early HIV-1 infection.
复制标题
阿昔洛韦对早期 HIV-1 感染期间单纯疱疹病毒 2 型血清阳性者的 HIV-1 设定点的影响。
DOI：
10.1086/655662
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Celum,Connie
中科院分区：
文献类型：
--
作者：
Kim,HNina;Wang,Jing;Hughes,James;Coombs,Robert;Sanchez,Jorge;Reid,Stewart;Delany-Moretlwe,Sinead;Cowan,Frances;Fuchs,Jonathan;Eshleman,SusanH;Khaki,Leila;McMahon,MoiraA;Siliciano,RobertF;Wald,Anna;Celum,Connie
We evaluated whether acyclovir suppression during human immunodeficiency virus type 1 (HIV-1) acquisition reduces HIV-1 set point, increases CD4 cell counts, and selects reverse-transcriptase mutations among 76 HIV-1 seroconverters identified in a placebo-controlled trial of twice-daily acyclovir (400 mg) for the prevention of HIV acquisition in herpes simplex virus type 2 (HSV-2)-seropositive persons (HIV Prevention Trials Network study 039). We found no significant difference in plasma HIV-1 RNA levels (P= .30) or CD4 cell counts (P= .85) between the acyclovir and placebo recipients. V75I and other mutations in HIV-1 reverse transcriptase reported from in vitro acyclovir studies were not observed. In conclusion, acyclovir suppression during HIV-1 seroconversion and the subsequent 6 months does not affect HIV-1 set point.
影响因子：
39.2
作者：
Schacker, TW;Hughes, JP;Corey, L
通讯作者：
Corey, L
影响因子：
6.4
作者：
Serwadda, D;Gray, RH;Wawer, MJ
通讯作者：
Wawer, MJ