New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes.
New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes.
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新型 8-芳基-7-脱氮鸟嘌呤细胞渗透性荧光探针。
DOI：
10.1016/j.bmcl.2015.08.054
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发表时间：
2015
影响因子：
2.7
通讯作者：
Khramtsov,ValeryV
中科院分区：
文献类型：
--
作者：
Dhimitruka,Ilirian;Eubank,TimothyD;Gross,AmyC;Khramtsov,ValeryV
完成了荧光8-芳基-(7-去氮鸟嘌呤)的一步合成。探针在各种有机和水溶液中显示出从蓝到绿的高量子产率荧光，高消光系数和大的斯托克斯位移，通常超过100 nm。该探针具有很强的细胞渗透性，一次在细胞内就能显示出稳定的明亮荧光，因此适合于生物传感器的设计。
A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors.