Gender alters the high-density lipoprotein cholesterol response to cardiac rehabilitation.
Gender alters the high-density lipoprotein cholesterol response to cardiac rehabilitation.
复制标题
性别改变高密度脂蛋白胆固醇对心脏康复的反应。
DOI：
10.1097/00008483-200407000-00007
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Ades,PhilipA
中科院分区：
文献类型：
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作者：
Savage,PatrickD;Brochu,Martin;Ades,PhilipA
目的：高密度脂蛋白胆固醇（HDL-C）水平降低是冠心病发生和进展的一个重要的独立危险因素。本研究评估了心脏康复运动训练对HDL-C和其他脂质亚组分的影响，密切关注性别和基线values.METHODS的作用：研究人群包括340例冠心病患者谁参加了门诊心脏康复，并完成了36届运动超过12周的时间。使用国家胆固醇教育小组ATP III指南创建HDL-C类别，患者在基线时分为四个亚组：（1）高HDL-C男性，（2）低HDL-C男性，（3）高HDL-C女性，（4）低HDL-C女性。0001）。在基线HDL-C高的患者中，女性HDL-C增加了8.4%，而男性没有变化（0.9%）（P<0.05）。001组之间）。此外，低HDL-C的女性比男性有更大的改善（15.3%比11.5%，P<0.05）。03）。结论：研究结果表明，尽管健身和身体成分发生了类似的变化，但女性在心脏康复后HDL-C的改善比男性更大。无论基线HDL-C如何，女性HDL-C均有所改善，而只有低HDL-C的男性HDL-C升高。这些结果描述了心脏康复对基于性别的HDL-C变化的不同影响。临床医生在评估个体的风险因素目标和治疗方案时应考虑性别的影响。
PURPOSE:A reduced level of high-density lipoprotein cholesterol (HDL-C) is a powerful independent risk factor for the development and progression of coronary heart disease. This study assessed the effects of cardiac rehabilitation exercise training on HDL-C and other lipid subfractions, giving close attention to the role of gender and baseline values.METHODS:The study population consisted of 340 patients with coronary heart disease who enrolled in outpatient cardiac rehabilitation and completed 36 sessions of exercise over a 12-week period. With the National Cholesterol Education Panel ATP III guidelines used to create categories of HDL-C, patients were stratified at baseline into four subgroups:(1) males with high HDL-C,(2) males with low HDL-C,(3) women with high HDL-C, and (4) women with low HDL-C.RESULTS:Overall, women experienced a significantly greater improvement in HDL-C after exercise training than men (14% vs 7.1%; P<. 0001). Among the patients with a high HDL-C at baseline, the women increased HDL-C by 8.4%, whereas there was no change (0.9%) in the men (P<. 001 between groups). Additionally, the women with low HDL-C experienced a significantly greater improvement than the men (15.3% vs 11.5%, P<. 03).CONCLUSIONS:The study results demonstrate that women experience a greater improvement in HDL-C with cardiac rehabilitation than men despite similar changes in fitness and body composition. Women, regardless of baseline HDL-C, demonstrated improvements in HDL-C, whereas only men with low HDL-C experienced an increase in HDL-C. These results describe a differing impact of cardiac rehabilitation on changes in HDL-C based on gender. Clinicians should consider the impact of gender when assessing an individual’s risk factor goals and therapeutic options.