Petasis-Type gem-Difluoroallylation Reactions Assisted by the Neighboring Hydroxyl Group in Amines.
Petasis-Type gem-Difluoroallylation Reactions Assisted by the Neighboring Hydroxyl Group in Amines.
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DOI：
10.1021/acs.orglett.8b00721
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发表时间：
2018-04
期刊：
影响因子：
5.2
通讯作者：
Xing Yang;Ze-Hun Cao;Yang Zhou;Feng Cheng;Zi-Wei Lin;Z. Ou;Ye Yuan;Yiyong Huang
中科院分区：
文献类型：
--
作者：
Xing Yang;Ze-Hun Cao;Yang Zhou;Feng Cheng;Zi-Wei Lin;Z. Ou;Ye Yuan;Yiyong Huang
A three-component Petasis-type gem-difluoroallylation reaction of using pinacol gem-difluoroallylboronates, aldehydes or isatin, and β-amino alcohols enabled by the neighboring hydroxyl group in amine is reported, affording various racemic and chiral gem-difluorohomoallylamine derivatives with good to excellent results. Based on the control experiment and stereochemistry of the product, a proposed reaction pathway is illustrated to clarify the origin of regio- and stereoselectivity under protic solvent conditions.
