Alterations of Na+ currents in myocytes from epicardial border zone of the infarcted heart - A possible ionic mechanism for reduced excitability and postrepolarization refractoriness
Alterations of Na+ currents in myocytes from epicardial border zone of the infarcted heart - A possible ionic mechanism for reduced excitability and postrepolarization refractoriness
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DOI：
10.1161/01.res.81.1.110
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发表时间：
1997-07-01
影响因子：
20.1
通讯作者：
Boyden, PA
中科院分区：
文献类型：
--
作者：
Pu, JL;Boyden, PA
Previously, we have shown abnormalities in (V) over bar (max) and in the recovery of (V) over bar (max) in myocytes dispersed from the epicardial border zone (EBZ) of the 5-day infarcted canine heart (myocytes from the EBZ [IZs]). Thus, we sought to determine the characteristics of the whole-cell Na+ current I-Na) in IZs and compare them with the I-Na of cells from noninfarcted hearts (myocytes from noninfarcted epicardium [NZs]). I-Na was recorded using patch-clamp techniques under conditions that eliminated contaminating currents and con trolled I-Na for measurement (19 degrees C, 5 mmol/L [Na+](0)). Peak I-Na density (at -25 mV) was significantly reduced in IZs (4.9+/-0.44 pA/pF, n=36) versus NZs (12.8+/-0.55 pA/pF, n=54; P
