Pertussis Toxin Promotes Pulmonary Hypertension in an Infant Mouse Model of Bordetella pertussis Infection.
Pertussis Toxin Promotes Pulmonary Hypertension in an Infant Mouse Model of Bordetella pertussis Infection.
复制标题
百日咳毒素在百日咳博德特氏菌感染的婴儿小鼠模型中促进肺动脉高压。
DOI：
10.1093/infdis/jiab325
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Carbonetti,NicholasH
中科院分区：
文献类型：
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作者：
Scanlon,KarenM;Chen,Ling;Carbonetti,NicholasH
百日咳是由百日咳杆菌引起的一种反复出现的疾病，可导致婴儿出现严重的疾病表现，包括肺动脉高压(PH)。百日咳引起的PH是感染性死亡的主要危险因素，但促进PH的分子机制尚不清楚，目前尚无有效的治疗方法。我们检查了B。用Fulton指数、右心导管法或多普勒超声心动图建立婴幼儿和成年小鼠百日咳诱发的PH模型。我们的结果表明，B。百日咳所致的PH与年龄有关，且依赖于细菌对百日咳毒素的表达。因此，百日咳毒素靶向治疗可能会改善PH和致命的婴儿感染。
Pertussis, caused byBordetella pertussis, is a reemerging disease that can produce severe disease manifestations in infants, including pulmonary hypertension (PH).B. pertussis-induced PH is a major risk factor for infection-induced death, but the molecular mechanisms promoting PH are unknown and there is no effective treatment. We examinedB. pertussis-induced PH in infant and adult mouse models of pertussis by Fulton index, right heart catheterization, or Doppler echocardiogram. Our results demonstrate thatB. pertussis-induced PH is age related and dependent on the expression of pertussis toxin by the bacterium. Hence, pertussis toxin-targeting treatments may ameliorate PH and fatal infant infection.