Nuclear pre-mRNA splicing in yeast.
Nuclear pre-mRNA splicing in yeast.
复制标题
酵母中的核前 mRNA 剪接。
DOI：
10.1002/yea.320050604
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
WoolfordJr,JL
中科院分区：
文献类型：
--
作者：
WoolfordJr,JL
Many nuclear, organellar, and viral genes encoding messenger RNA, ribosomal RNA, or transfer RNA contain intervening sequences or introns. Split genes have even been found in prokaryotic bacteriophage genomes. Expression of these genes requires the precise removal of introns from the primary transcripts and the splicing together of the remaining sequences, or exons, in the correct order. The precision required in splicing is indeed quite impressive when one realizes that some nuclear genes contain as many as 50 introns, some introns are as long as 100 000 nucleotides, and some exons are as short as six nucleotides. An added complexity is that temporal or spatial specific modulation of splicing patterns is used to vary the amount or precise sequence of mature transcripts derived from split genes.’Such alternative splicing, combined with differential utilization of sites of initiation of termination of transcription, differential processing of transcript termini, or variations in posttranslational processing and modification of proteins could generate an enormous diversity of products expressed from individual genes.
