Platelet MicroRNAs: An Overview.
Platelet MicroRNAs: An Overview.
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DOI：
10.1016/j.tmrv.2015.08.002
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发表时间：
2015-10
影响因子：
4.5
通讯作者：
Atreya CD
中科院分区：
文献类型：
--
作者：
Dahiya N;Sarachana T;Vu L;Becker KG;Wood WH 3rd;Zhang Y;Atreya CD
MicroRNAs （miRNAs）是一种短的约22个核苷酸的非编码RNA，通过抑制翻译或降解信使RNA转录物来影响许多基因的表达和细胞过程。血小板miRNA的表达在血小板体外储存和血小板相关疾病中受到干扰。尽管基于生物信息学的miRNA靶标预测已经建立，但miRNA在血小板生物学中的作用的直接实验验证一直相当缓慢。尽管如此，靶标预测研究在指导设计适当的实验以测试与血小板功能的一般机制和疾病以及离体储存相关的“储存损伤”相关的特定miRNA：信使RNA相互作用方面是有价值的，“储存损伤”是一个集合术语，用于包括储存血小板中发生的生理、生化和形态学变化。本文将重点介绍新出现的人类血小板miRNA研究，强调其在输血医学领域的潜在作用，包括血小板信号通路的调节、血小板相关疾病的标志物、基因表达的远程影响因子（细胞间生物调节剂）以及血小板储存和减少病原体治疗的潜在质量标志物。
MicroRNAs (miRNAs) are short ~22-nucleotide noncoding RNA that have been found to influence the expression of many genes and cellular processes by either repressing translation or degrading messenger RNA transcripts. Platelet miRNA expression has been shown to be perturbed during ex vivo storage of platelets and in platelet-associated disorders. Although bioinformatics-based miRNA target predictions have been established, direct experimental validation of the role of miRNAs in platelet biology has been rather slow. Target prediction studies are, nonetheless, valuable in directing the design of appropriate experiments to test specific miRNA:messenger RNA interactions relevant to the underlying mechanisms of platelet function in general and in disease as well as in ex vivo storage-associated “storage lesions,” a collective term used to include physiologic, biochemical, and morphologic changes that occur in stored platelets. This brief review will focus on emerging human platelet miRNA studies to emphasize their potential role relevant to transfusion medicine field in terms of regulating platelet signaling pathways, markers of platelet associated disorders, and remote impactors of gene expression (intercellular biomodulators) as well as potential platelet quality markers of storage and pathogen reduction treatments.
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影响因子：
3.3
作者：
Osman A;Hitzler WE;Meyer CU;Landry P;Corduan A;Laffont B;Boilard E;Hellstern P;Vamvakas EC;Provost P
通讯作者：
Provost P
DOI：
10.1111/j.1538-7836.2009.03700.x
发表时间：
2010-02
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Kondkar AA;Bray MS;Leal SM;Nagalla S;Liu DJ;Jin Y;Dong JF;Ren Q;Whiteheart SW;Shaw C;Bray PF
通讯作者：
Bray PF
DOI：
10.3324/haematol.12706
发表时间：
2008-07-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Bruchova, Hana;Merkerova, Michaela;Prchal, Josef T.
通讯作者：
Prchal, Josef T.
影响因子：
3.3
作者：
De Santis, Giuseppe;Ferracin, Manuela;Granieri, Enrico
通讯作者：
Granieri, Enrico
影响因子：
20.3
作者：
Laffont, Benoit;Corduan, Aurelie;Provost, Patrick
通讯作者：
Provost, Patrick