Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae
Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae
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DOI：
10.1080/00365521.2020.1753806
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发表时间：
2020-04-22
影响因子：
1.9
通讯作者：
Hvas, Christian Lodberg
中科院分区：
文献类型：
--
作者：
Bahl, Martin Iain;Jorgensen, Simon Mark Dahl;Hvas, Christian Lodberg
艰难梭菌感染可能并发其他病原体的合并感染。我们在这里描述了粪便微生物群移植的成功应用，以消除伴随C。艰难梭菌和广泛耐药（XDR）产KPC肺炎克雷伯菌。供体微生物群有效地植入患者体内，并且在6个月的随访期间，供体样微生物聚集体在患者体内持续存在。该报告探讨了供体微生物群根除和取代多重耐药微生物的潜力。
Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace multi-resistant microorganisms.