An efficient waste-free oxidative coupling via regioselective C-H bond cleavage: Rh/Cu-catalyzed reaction of benzoic acids with alkynes and acrylates under air
An efficient waste-free oxidative coupling via regioselective C-H bond cleavage: Rh/Cu-catalyzed reaction of benzoic acids with alkynes and acrylates under air
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DOI：
10.1021/ol070406h
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发表时间：
2007-03-29
期刊：
影响因子：
5.2
通讯作者：
Miura, Masahiro
中科院分区：
文献类型：
--
作者：
Ueura, Kenji;Satoh, Tetsuya;Miura, Masahiro
在铑/铜催化体系存在下，苯甲酸与内炔在空气中直接氧化偶联，得到相应的异香豆素衍生物。除了水之外，反应不形成废物。在类似的条件下，与丙烯酸酯的有氧偶联也顺利进行，通过二乙烯化和随后的环化产生7-乙烯基苯酞衍生物。
The direct oxidative coupling of benzoic acids with internal alkynes proceeds efficiently in the presence of a rhodium/copper catalyst system under air to afford the corresponding isocoumarin derivatives. The reaction forms no wastes except for water. Under similar conditions, the aerobic coupling with acrylates also takes place smoothly to produce 7-vinylphthalide derivatives via divinylation and subsequent cyclization.