Polyploidy in differentiation and evolution.
Polyploidy in differentiation and evolution.
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分化和进化中的多倍体。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
W. Nagl
中科院分区：
文献类型：
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作者：
W. Nagl
体细胞和生殖（生殖系）多倍性是比一般认为的更广泛的生物体中传播的现象。本文综述了在正常和病理分化中多倍体化和相关事件的发生、它们公认的主要功能以及多倍体细胞核的结构特异性，并讨论了个体发育和系统发育事件之间的关系。导致多倍体状态的机制，以及其他过程导致基因组条件不同的二倍体（如DNA复制不足，基因扩增和染色质消除），简要概述。总之，所描述的染色体DNA的各种变化被视为支持真核基因组的“流体”或动态组织的范例的证据，作为基因表达的控制论反馈调节系统的一部分。提出了一个模型，统一方面的DNA变异，染色质结构，和多样化的个体发育和胚胎发育。
Somatic and generative (germ-line) polyploidy are more widely spread phenomena among living organisms than generally thought. The occurrence of polyploidization and related events in normal and pathological differentiation, their recognized main functions, as well as the structural specificities of polyploid nuclei are reviewed, and the relationship between ontogenetic and phylogenetic events is discussed. The mechanisms leading to the polyploid state, as well as other processes resulting in a genomic condition different from the diploid one (such as DNA under-replication, gene amplification, and chromatin elimination), are briefly sketched. The various changes in chromosomal DNA described are, in conclusion, seen as evidence supporting the paradigm of a "fluid" or dynamic organization of the eukaryotic genome, as being part of a cybernetic feedback regulation system of gene expression. A model is proposed that unifies the aspects of DNA variation, chromatin structure, and diversification in ontogenesis and phylogenesis.
基因扩增、耐药性和癌症。
影响因子：
11.2
作者：
Schimke,RT
通讯作者：
Schimke,RT