Role of prolactin in the lactational amenorrhea of the rhesus monkey (Macaca mulatta).
Role of prolactin in the lactational amenorrhea of the rhesus monkey (Macaca mulatta).
复制标题
催乳素在恒河猴（Macaca mulatta）哺乳期闭经中的作用。
DOI：
10.1095/biolreprod25.2.370
复制
发表时间：
1981
影响因子：
3.6
通讯作者：
Knobil,E
中科院分区：
文献类型：
--
作者：
Schallenberger,E;Richardson,DW;Knobil,E
研究了催乳素在哺乳诱导的促性腺激素分泌抑制中的作用，在产后恒河猴中，一些被允许哺乳，而另一些则不被允许。所有动物血清催乳素（PRL）均被抑制。与未哺乳的对照组相比，哺乳猴产后黄体生成素（LH）基础水平的上升和雌二醇正反馈作用的反应延迟。黄体生成素（LH）的抑制作用较促卵泡激素（FSH）明显。这些发现表明，高催乳素血症可能不能完全解释哺乳期间促性腺激素分泌的抑制，与哺乳有关的感觉输入可能通过其他机制影响下丘脑对促性腺激素分泌的控制。
The role of prolactin in suckling-induced suppression of gonadotropin secretion was investigated in postpartum rhesus monkeys treated with bromocriptine, some of which were allowed to suckle their young while others were not. Serum prolactin (PRL) was suppressed in all animals. The postpartum rise in the basal levels of luteinizing hormone (LH) and the response to the positive feedback action of estradiol were delayed in the suckled monkeys when compared with their nonsuckled controls. The inhibition of LH secretion was more pronounced than that of follicle stimulating hormone (FSH). These findings permit the conclusion that hyperprolactinemia may not entirely account for the inhibition of gonadotropin secretion during lactation and that sensory inputs associated with suckling may affect the hypothalamic control of gonadotropin secretion by some other mechanism.