Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.

Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.
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血清肝酶全基因组关联研究提示多种代谢和肝脏病理学。

DOI:
10.1038/s41467-020-20870-1
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发表时间:
2021-02-05
影响因子:
16.6
通讯作者:
Speliotes EK
Speliotes EK
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Chen VL;Du X;Chen Y;Kuppa A;Handelman SK;Vohnoutka RB;Peyser PA;Palmer ND;Bielak LF;Halligan B;Speliotes EK

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血清肝酶浓度是肝病最常用的实验室标志物,肝病是死亡的主要原因。我们对来自英国生物银行和日本生物银行的肝酶全基因组关联研究进行了荟萃分析。我们确定了160个以前未报道的独立丙氨酸氨基转移酶,190个天冬氨酸氨基转移酶和199个碱性磷酸酶基因组显著关联,其中一些影响多种不同的酶。相关变异涉及表现出不同肝细胞类型表达并促进一系列代谢和肝脏疾病的基因。这些发现提供了深入了解肝脏和其他代谢性疾病的病理生理学与血清肝酶浓度。血清肝酶被用作肝病的标志物,其浓度部分受遗传因素的影响。在这里,作者荟萃分析了英国生物银行和日本生物银行的全基因组关联研究,以评估三种肝酶与肝脏和其他代谢疾病的关联。
Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of genome-wide association studies of liver enzymes from UK BioBank and BioBank Japan. We identified 160 previously-unreported independent alanine aminotransferase, 190 aspartate aminotransferase, and 199 alkaline phosphatase genome-wide significant associations, with some affecting multiple different enzymes. Associated variants implicate genes that demonstrate diverse liver cell type expression and promote a range of metabolic and liver diseases. These findings provide insight into the pathophysiology of liver and other metabolic diseases that are associated with serum liver enzyme concentrations. Serum liver enzymes are used as markers of liver disease, their concentration influenced in part by genetic factors. Here the authors meta-analyse genome-wide association studies on the UK Biobank and BioBank Japan to evaluate the association of three liver enzymes with liver and other metabolic diseases.
DOI: 10.1038/ng.3211
发表时间: 2015-03
期刊: NATURE GENETICS
影响因子: 30.8
作者:
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发表时间: 2014-06-17
影响因子: 11.1
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DOI: 10.1038/ng.627
发表时间: 2010-08
期刊: Nature genetics
影响因子: 30.8
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DOI: 10.1038/ng.970
发表时间: 2011-10-16
期刊: Nature genetics
影响因子: 30.8
作者:
通讯作者: --