BEAM study (Breathing, Education, Awareness, Movement): a randomised controlled feasibility trial of tai chi exercise in patients with COPD.
BEAM study (Breathing, Education, Awareness, Movement): a randomised controlled feasibility trial of tai chi exercise in patients with COPD.
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DOI：
10.1136/bmjresp-2020-000697
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发表时间：
2020-11
影响因子：
4.1
通讯作者：
Moy ML
中科院分区：
文献类型：
--
作者：
Yeh GY;Litrownik D;Wayne PM;Beach D;Klings ES;Reyes Nieva H;Pinheiro A;Davis RB;Moy ML
尽管治疗进展，慢性阻塞性肺疾病（COPD）的管理仍然很复杂。人们越来越关注多维度的身心锻炼，以改善COPD负担的身体和心理方面。在美国，很少有关于太极拳（TC）的数据，太极拳是一种结合身体活动、呼吸和意识的身心运动。我们在美国学术医疗环境中探索了TC治疗COPD的可行性和初步疗效。COPD全面阻塞性肺疾病（GOLD）2-4期患者被随机分配至12周TC计划或教育对照组。在12周时，TC中的那些人再次随机继续维持课程或不进一步探索最佳持续时间。所有组均随访至24周。对可行性/安全性参数进行了连续性分析。初步评估了症状（呼吸困难、疲劳）、健康相关生活质量（慢性呼吸问卷CRQ）、认知-情感测量（情绪、COPD自我效能）和功能状态（6分钟步行试验、下肢力量、灵活性、体力活动）的组间差异。92例受试者接受随机化（N=61例TC，N=31例教育）。平均年龄为68±8岁，66%为男性，1 s %预测的平均用力呼气量为57±13，28%为GOLD 3-4期。总体保留率为85%。发生了19起不良事件，大多数是与研究无关的COPD急性加重。从基线至12周，在CRQ-总评分中，组间改善有利于TC（科恩d效应量（ES）=0.46;调整平均差异（AMD）=0.31），CRQ-情绪（ES=0.54; AMD=0.49），抑郁症流行病学研究中心（ES=−0.37; AMD=2.39）和患者报告结局测量信息系统（PROMIS）-疲劳（ES=−0.34; AMD=−0.17）。从基线至24周，CRQ-呼吸困难的改善有利于TC（ES=0.41; AMD=0.46）。在TC参与者中，维持课程对自我效能（ES=-0.69; AMD=-0.40），6分钟步行（ES=0.56; AMD=49.26英尺），PROMIS疲劳（ES=-0.41; AMD=-0.28）和椅子站立（0.43; AMD=0.56）有积极影响。结论TC治疗COPD是安全可行的。初步分析支持在改善生活质量，认知情绪健康和功能方面的潜在适度作用，应进一步研究。NCT01551953。BIDMC 2010 P-000412; VA 2540。
Despite therapeutic advances, the management of chronic obstructive pulmonary disease (COPD) remains complex. There is growing interest in multidimensional, mind-body exercises to improve both physical and psychosocial aspects of COPD burden. Few US data are available in this population on tai chi (TC) a mind-body exercise incorporating physical activity, breathing and mindful awareness. We explored feasibility and preliminary efficacy of TC in COPD in an US academic medical setting. Patients with COPD Global Obstructive Lung Disease (GOLD) stages 2–4 were randomised to a 12-week TC programme or education control. At 12 weeks, those in TC were randomised again to continue in maintenance classes or not to further explore optimal duration. All groups were followed to 24 weeks. Feasibility/safety parameters were analysed descriptively. Preliminary between-group differences were estimated in symptoms (dyspnoea, fatigue), health-related quality-of-life (Chronic Respiratory Questionnaire CRQ), cognitive-emotional measures (mood, COPD self-efficacy) and functional status (6 min walk test, lower body strength, flexibility, physical activity). Ninety-two subjects were randomised (N=61 TC, N=31 education). Mean age was 68±8 years, 66% male, mean forced expiratory volume in 1 s % predicted 57±13, 28% were GOLD stage 3–4. Overall retention was 85%. Nineteen adverse events occurred, most being study-unrelated COPD exacerbations. From baseline to 12 weeks, there were between-group improvements favouring TC, in CRQ-total (Cohen’s d effect size (ES)=0.46; adj mean diff (AMD)=0.31), CRQ-emotion (ES=0.54; AMD=0.49), Centre for Epidemiologic Studies Depression (ES=−0.37; AMD=2.39) and Patient-Reported Outcome Measurement Information System (PROMIS)-fatigue (ES=−0.34; AMD=−0.17). From baseline to 24 weeks, there was an improvement favouring TC in CRQ-dyspnoea (ES=0.41; AMD=0.46). Among TC participants, there was a positive effect of maintenance classes on self-efficacy (ES=−0.69; AMD=−0.40), 6 min walk (ES=0.56; AMD=49.26 feet), PROMIS-fatigue (ES=−0.41; AMD=−0.28) and chair stand (0.43; AMD=0.56). TC in patients with COPD is feasible and safe. Preliminary analyses support a potential modest role in improving quality-of-life, cognitive-emotional health and function that should be further studied. NCT01551953. BIDMC 2010P-000412; VA 2540.
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影响因子：
3.1
作者：
Hekler EB;Buman MP;Haskell WL;Conway TL;Cain KL;Sallis JF;Saelens BE;Frank LD;Kerr J;King AC
通讯作者：
King AC
影响因子：
8.3
作者：
Jackson, Bradford E;Coultas, David B;Bae, Sejong
通讯作者：
Bae, Sejong
影响因子：
4.1
作者：
Boutou, Afroditi K.;Tanner, Rebecca J.;Hopkinson, Nicholas S.
通讯作者：
Hopkinson, Nicholas S.
影响因子：
158.5
作者：
Celli, BR;Cote, CG;Cabral, HJ
通讯作者：
Cabral, HJ
DOI：
10.1164/rccm.201310-1863pp
发表时间：
2014-02-01
影响因子：
24.7
作者：
Jones, Paul W.;Beeh, Kai M.;Wedzicha, Jadwiga A.
通讯作者：
Wedzicha, Jadwiga A.