Thirty years of ISFETOLOGY - What happened in the past 30 years and what may happen in the next 30 years
Thirty years of ISFETOLOGY - What happened in the past 30 years and what may happen in the next 30 years
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DOI：
10.1016/s0925-4005(02)00301-5
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发表时间：
2003-01-01
影响因子：
8.4
通讯作者：
Bergveld, P
中科院分区：
文献类型：
--
作者：
Bergveld, P
本文介绍了ISFET的发展历史背景，但不限于此。基于理论、技术、仪器和许多具体应用的经验的发展，还定义了未来的项目，例如关于细胞酸化、REFET偏置和基于与固定化带电分子（水凝胶）的（生物）化学相互作用的局部压力感应的全新FET传感器范围。并讨论了目前的专利和市场状况。它的结论是，在过去的30年里，ISFET的研究和开发取得了持续的进展，定期的基础上，但实际应用仍然落后，特别是关于动态使用的ISFET与集成的pH执行器相结合。新提出的研究项目可能会再持续30年。(C)2002 Elsevier Science B.V.保留所有权利。
This paper describes the development of ISFETs in an historical setting, but is not limited to that. Based on the development regarding the theory, the technology, the instrumentation and the experience with many specific applications, also future projects are defined, such as concerning cell acidification, REFET biasing and a complete new range of FET sensors based on local pressure induction by (bio)chemical interaction with immobilised charged molecules (hydrogels). Also the present patent and market position is discussed. It is concluded that in the past 30 years the ISFET research and development made continuous progress on a regular base, but the practical applications stayed behind, especially concerning the dynamic use of ISFETs in combination with an integrated pH actuator. The newly proposed research projects may be good for an other 30 years. (C) 2002 Elsevier Science B.V. All rights reserved.