Preparation of monodisperse polylactide microspheres by dispersion polymerization using a polymeric stabilizer with hydroxy groups.
Preparation of monodisperse polylactide microspheres by dispersion polymerization using a polymeric stabilizer with hydroxy groups.
复制标题
DOI：
10.1002/marc.200800620
复制
发表时间：
2009-02
影响因子：
4.6
通讯作者：
M. Muranaka;T. Ono
中科院分区：
文献类型：
--
作者：
M. Muranaka;T. Ono
以合成的高分子稳定剂为分散剂，通过分散聚合法制备了单分散聚乳酸（PDLLA）微球。聚合在二甲苯/庚烷（1：2，v/v）中在368 K下用聚[（甲基丙烯酸十二烷基酯）-共-（甲基丙烯酸2-羟乙酯）]（P（DMA-co-HEMA））进行3小时。P（DMA-co-HEMA）具有羟基作为假阴离子分散聚合的引发基团。所得聚乳酸微球的粒径为3.9 µm，粒径分布变异系数为4.3%。此外，从动态光散射测量的结果，它被发现，P（DMA-co-HEMA）和PDLLA接枝共聚物在溶液中形成胶束结构。
Monodisperse poly(D,L-lactide) (PDLLA) microspheres have been prepared by dispersion polymerization of D,L-lactide with a synthetic polymeric stabilizer. The polymerization is carried out in xylene/heptane (1:2, v/v) at 368 K for 3 h with poly[(dodecyl methacrylate)-co-(2-hydroxyethyl methacrylate)] (P(DMA-co-HEMA)). P(DMA-co-HEMA) has hydroxy groups as an initiation group for pseudoanionic dispersion polymerization. The particle diameter and the coefficient of variation concerning the diameter distribution of the obtained PDLLA microspheres are 3.9 µm and 4.3%, respectively. In addition, from the results of dynamic light scattering measurements, it is found that P(DMA-co-HEMA) and the PDLLA-grafted copolymer form a micellar structure in solution.