Genetic and Environmental Links Between Cognitive and Physical Functions in Old Age
Genetic and Environmental Links Between Cognitive and Physical Functions in Old Age
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DOI：
10.1093/geronb/gbn033
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发表时间：
2009-01-01
影响因子：
6.2
通讯作者：
Christensen, Kaare
中科院分区：
文献类型：
--
作者：
Johnson, Wendy;Deary, Ian J.;Christensen, Kaare
在老年时，认知功能和身体功能是相关的。了解这种相关性背后的遗传和环境影响之间的相关性有助于阐明可观察到的（表型）相关性的原因。我们根据丹麦老龄双胞胎纵向研究的 1,053 对双胞胎样本估算了这些相关性。认知功能通过向前和向后的数字跨度、即时和延迟记忆以及流畅性任务来测量。身体功能是通过自我报告进行身体活动（包括步行、跑步和爬楼梯）的能力来测量的。潜在变量表示之间的表型相关性为 46（95% 置信区间 0.27-0.65）。遗传相关性为 0.56（95% 置信区间 0.15-1.00），非共享环境相关性为 0.48（95% 置信区间 0.35-0.61）。我们讨论解释这些相关性的几种方法。
In old age, cognitive and physical functions are correlated. Knowing the correlations between genetic and environmental influences underlying this correlation can help to clarify the reasons for the observable (phenotypic) correlation. We estimated these correlations in a sample of 1,053 pairs of twins from the Longitudinal Study of Aging Danish Twins. Cognitive function was measured using forward and backward digit span, immediate and delayed memory, and fluency tasks. Physical function was measured using self-report of ability to carry out physical activities including walking, running, and climbing stairs. The phenotypic correlation between latent variable representations was.46 (95% confidence interval 0.27-0.65). The genetic correlation was .56 (95% confidence interval 0.15-1.00) and the nonshared environmental correlation .48 (95% confidence interval 0.35-0.61). We discuss several ways of interpreting these correlations.