Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease.
Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease.
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常染色体显性阿尔茨海默病神经学检查结果的模式和意义。
DOI：
10.1002/alz.12684
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ghett
中科院分区：
文献类型：
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作者：
Vöglein,Jonathan;Franzmeier,Nicolai;Morris,JohnC;Dieterich,Marianne;McDade,Eric;Simons,Mikael;Preische,Oliver;Hofmann,Anna;Hassenstab,Jason;Benzinger,TammieL;Fagan,Anne;Noble,JamesM;Berman,SarahB;Graff-Radford,NeillR;Ghett
IntroductionAs知识的神经系统检查结果在常染色体显性阿尔茨海默病（ADAD）是不完整的，我们的目的是确定的频率和意义的神经系统检查结果在ADAD.MethodsFrequencies的神经系统检查结果进行了比较症状性突变载体和非突变载体从显性遗传阿尔茨海默病网络（DIAN），以定义AD神经系统检查结果。AD神经系统检查的结果进行了分析频率，关联和预测值关于认知能力下降，并与脑萎缩的症状突变carriers.ResultsAD神经系统检查结果包括异常深腱反射，步态障碍，病理颅神经检查结果，震颤，异常手指鼻子和脚跟胫测试，和受损的运动强度。AD神经系统检查结果的频率为65.1%。在横断面上，具有AD神经系统检查结果的突变携带者显示出超过两倍的认知下降速度，并且具有更大的顶颞萎缩，包括海马萎缩。纵向上，AD神经系统检查结果预测随着时间的推移显着更大的下降。DiscussionADAD功能的神经系统检查结果，是有用的估计预后，并可能通知临床护理和治疗试验设计的一个独特的模式。
IntroductionAs knowledge about neurological examination findings in autosomal dominant Alzheimer disease (ADAD) is incomplete, we aimed to determine the frequency and significance of neurological examination findings in ADAD.MethodsFrequencies of neurological examination findings were compared between symptomatic mutation carriers and non mutation carriers from the Dominantly Inherited Alzheimer Network (DIAN) to define AD neurological examination findings. AD neurological examination findings were analyzed regarding frequency, association with and predictive value regarding cognitive decline, and association with brain atrophy in symptomatic mutation carriers.ResultsAD neurological examination findings included abnormal deep tendon reflexes, gait disturbance, pathological cranial nerve examination findings, tremor, abnormal finger to nose and heel to shin testing, and compromised motor strength. The frequency of AD neurological examination findings was 65.1%. Cross‐sectionally, mutation carriers with AD neurological examination findings showed a more than two‐fold faster cognitive decline and had greater parieto‐temporal atrophy, including hippocampal atrophy. Longitudinally, AD neurological examination findings predicted a significantly greater decline over time.DiscussionADAD features a distinct pattern of neurological examination findings that is useful to estimate prognosis and may inform clinical care and therapeutic trial designs.