A comparison of polymer substrates for photolithographic processing of flexible bioelectronics.
A comparison of polymer substrates for photolithographic processing of flexible bioelectronics.
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用于柔性生物电子学光刻加工的聚合物基材的比较。
DOI：
10.1007/s10544-013-9782-8
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发表时间：
2013
影响因子：
2.8
通讯作者：
Voit,Walter
中科院分区：
文献类型：
--
作者：
Simon,Dustin;Ware,Taylor;Marcotte,Ryan;Lund,BenjaminR;SmithJr,DennisW;DiPrima,Matthew;Rennaker,RobertL;Voit,Walter
柔性生物电子学包括新一代传感装置，其中与组织的受控相互作用增强了对体内生物过程的理解。然而，这种薄膜电子器件的制造与光刻工艺仍然是一个挑战，许多生物相容性聚合物。最近，基于丙烯酸酯和硫醇-烯/丙烯酸酯网络的两种形状记忆聚合物（SMP）系统被设计为用于软化神经界面的基底，其具有高于体温（37 °C）的玻璃化转变，使得材料对于插入到软组织中是刚性的，并且在生理条件下通过低吸湿性而软化。这两种基板，丙烯酸酯和硫醇-烯/丙烯酸酯SMP，相比，聚萘二甲酸乙二醇酯，聚碳酸酯，聚酰亚胺，和聚二甲基硅氧烷，已被广泛用于柔性电子研究和工业。这六个基板进行了比较，通过动态力学分析（DMA），热重分析（TGA），和溶胀研究。使用光学轮廓测量和电学测量来评估SMP基板上金和铬/金薄膜的完整性，作为玻璃化转变温度以上、以下和整个玻璃化转变温度的加工温度的函数。交联密度，粘附力和固化应力的影响被证明在这些薄膜材料的稳定性中起着至关重要的作用，并提出了一个指导未来设计的响应性聚合物材料适合神经接口。最后，硫醇-烯/丙烯酸酯基板上制造的神经接口表现出长期的保真度，通过bothin vitroimpedance光谱和记录驱动局部场电位8周在实验室大鼠的听觉皮层。
Flexible bioelectronics encompass a new generation of sensing devices, in which controlled interactions with tissue enhance understanding of biological processesin vivo. However, the fabrication of such thin film electronics with photolithographic processes remains a challenge for many biocompatible polymers. Recently, two shape memory polymer (SMP) systems, based on acrylate and thiol-ene/acrylate networks, were designed as substrates for softening neural interfaces with glass transitions above body temperature (37 °C) such that the materials are stiff for insertion into soft tissue and soften through low moisture absorption in physiological conditions. These two substrates, acrylate and thiol-ene/acrylate SMPs, are compared to polyethylene naphthalate, polycarbonate, polyimide, and polydimethylsiloxane, which have been widely used in flexible electronics research and industry. These six substrates are compared via dynamic mechanical analysis (DMA), thermogravimetric analysis (TGA), and swelling studies. The integrity of gold and chromium/gold thin films on SMP substrates are evaluated with optical profilometry and electrical measurements as a function of processing temperature above, below and through the glass transition temperature. The effects of crosslink density, adhesion and cure stress are shown to play a critical role in the stability of these thin film materials, and a guide for the future design of responsive polymeric materials suitable for neural interfaces is proposed. Finally, neural interfaces fabricated on thiol-ene/acrylate substrates demonstrate long-term fidelity through bothin vitroimpedance spectroscopy and the recording of driven local field potentials for 8 weeks in the auditory cortex of laboratory rats.