Resting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion
Resting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion
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DOI：
10.1111/acps.12573
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发表时间：
2016-08-01
影响因子：
6.7
通讯作者：
Zepf, F. D.
中科院分区：
文献类型：
--
作者：
Biskup, C. S.;Helmbold, K.;Zepf, F. D.
目的：在神经精神障碍患者中，包括注意缺陷多动障碍（ADHD），已经描述了默认模式网络（DMN）的改变，并且已知神经递质5-羟色胺（5-HT）调节DMN活性。本研究旨在探讨5-HT对年轻ADHD患者DMN及其功能连接（FC）的作用。方法：对12例年轻ADHD患者和10例健康对照者（年龄均为12-17岁）进行急性色氨酸耗竭（ATD），随后减少脑5-HT合成。3小时后的挑战摄入量（ATD或平衡的控制条件，BAL），静息状态fMRI scans were given.Results：在患者中，ATD导致衰减FC的右上级运动前皮质（BA 6）与DMN，相当的程度发现在控制后BAL管理。ATD降低FC的左侧躯体感觉皮层（BA 3）与DMN，独立的因素组，但具有更强的影响controls.Conclusions：数据显示FC之间的BA 6和3，已知相关的运动规划和感觉知觉，和DMN，从而可能指向ATD有利于神经规划的运动活动在ADHD患者的神经调节。
Objective: Alterations of the default mode network (DMN) have been described in patients with neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), and the neurotransmitter serotonin (5-HT) is known to modulate DMN activity. This study aimed to explore the role of 5-HT on the DMN and its functional connectivity (FC) in young patients with ADHD.Methods: Young male patients with ADHD (n = 12) and healthy controls (n = 10) (both aged 12-17 years) were subjected to acute tryptophan depletion (ATD) and subsequently diminished brain 5-HT synthesis. Three hours after challenge intake (ATD or a balanced control condition, BAL), resting state fMRI scans were obtained.Results: In patients, ATD led to attenuated FC of the right superior premotor cortex (BA 6) with the DMN, comparable to the extent found in controls after BAL administration. ATD lowered FC of the left somatosensory cortex (BA 3) with the DMN, independently of the factor group, but with stronger effects in controls.Conclusions: Data reveal a serotonergic modulation of FC between BA 6 and 3, known to be relevant for motor planning and sensory perception, and the DMN, thereby possibly pointing toward ATD acting beneficially on neural planning of motor activity in patients with ADHD.