Mild traumatic brain injury and fatigue: A prospective longitudinal study
Mild traumatic brain injury and fatigue: A prospective longitudinal study
复制标题
DOI：
10.3109/02699052.2010.531687
复制
发表时间：
2010-01-01
期刊：
影响因子：
1.9
通讯作者：
Flett, Ross
中科院分区：
文献类型：
--
作者：
Norrie, Joan;Heitger, Marcus;Flett, Ross
主要目标：研究轻度创伤性脑损伤（MTBI）后6个月内疲劳的患病率、严重程度、预测因子和协变量。研究设计：纵向前瞻性研究，包括263名患有MTBI的成年人。参与者完成了疲劳严重程度量表（FSS），Rivermead脑震荡后症状问卷（RPSQ），医院焦虑和抑郁量表（HADS）和简明健康调查表第2版（SF-36 v2）。共有159名参与者提供了完整的数据。关键指标;患病率-RPSQ项目6：严重程度-FSS。使用ANOVA检验时间对疲劳患病率和严重程度的影响。多元回归分析确定了统计学显著的协变量。主要结果和结果：MTBI后疲劳患病率在1周、3个月和6个月分别为68%、38%和34%。在前3个月内，时间有很强的影响，疲劳患病率和严重程度之间存在中度到高度的相关性。早期疲劳强烈预测后期疲劳;抑郁，但不是焦虑是一个预测因素。疲劳被视为懒惰的家人或朋友在30%的cases.Conclusions：后MTBI疲劳是一种持续的脑震荡后症状，加重抑郁症，但不是焦虑。它在前3个月减少，然后变得相对稳定，这表明最佳干预位置是在MTBI后3个月或更长时间。
Primary objective: To examine fatigue prevalence, severity, predictors and co-variates over 6 months post-mild traumatic brain injury (MTBI).Research design: Longitudinal prospective study including 263 adults with MTBI.Procedures: Participants completed the Fatigue Severity Scale (FSS), Rivermead Post-concussion Symptoms Questionnaire (RPSQ), Hospital Anxiety and Depression Scale (HADS) and the Short Form 36 Health Survey-Version 2 (SF-36v2). Complete data were available for 159 participants. Key measures; prevalence-RPSQ Item 6: severity-FSS. The effect of time on fatigue prevalence and severity was examined using ANOVA. Multiple regression analysis identified statistically significant covariates.Main outcomes and results: Post-MTBI fatigue prevalence was 68%, 38% and 34% at 1 week, 3 and 6 months, respectively. There was a strong effect for time over the first 3 months and moderate-to-high correlations between fatigue prevalence and severity. Early fatigue strongly predicted later fatigue; depression, but not anxiety was a predictor. Fatigue was seen as laziness by family or friends in 30% of cases.Conclusions: Post-MTBI fatigue is a persistent post-concussion symptom, exacerbated by depression but not anxiety. It diminishes in the first 3 months and then becomes relatively stable, suggesting the optimum intervention placement is at 3 months or more post-MTBI.