Hypersecretion of a new corticosteroid, 18-hydroxycortisol in two types of adrenocortical hypertension.
Hypersecretion of a new corticosteroid, 18-hydroxycortisol in two types of adrenocortical hypertension.
复制标题
两种类型的肾上腺皮质高血压中一种新型皮质类固醇 18-羟基皮质醇的分泌过多。
DOI：
--
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Michael D. Chu
中科院分区：
文献类型：
--
作者：
S. Ulick;Michael D. Chu
原发性醛固酮增多症患者尿游离类固醇组分中最丰富的物质已被确定为18-羟基皮质醇。18-羟皮质醇很可能是肾上腺皮质分泌产物，而不是外周代谢产物，因为它是由醛固酮瘤组织切片大量合成的。18-羟基皮质醇的生物合成发生在皮质醇而不是18-羟基皮质酮;也就是说，17 α-先于18-羟基化。皮质醇18-羟基化似乎与该位置的其他两种肾上腺皮质羟基化无关。该途径在正常人肾上腺皮质中存在很小程度，并且仅受到ACTH的适度刺激。皮质醇18-羟基化在两种情况下明显加重：在醛固酮瘤细胞中，它的存在可能有助于区分肿瘤与双侧增生;在ACTH刺激的醛固酮增多症中，它代表了第一个定性的类固醇生化异常，因此可能有助于诊断和遗传研究。18-羟基皮质醇对这两种类型醛固酮增多症盐皮质激素过量临床表现严重程度的可能贡献仍有待探讨。
The most abundant substance in the urinary free steroid fraction of patients with primary aldosteronism has been identified as 18-hydroxycortisol. 18-hydroxycortisol is very likely an adrenocortical secretory product rather than a peripheral metabolite, since it is abundantly synthesized by aldosteronoma tissue slices. The biogenesis of 18-hydroxycortisol takes place from cortisol rather than from 18-hydroxycorticosterone; that is, 17 alpha-precedes 18-hydroxylation. Cortisol 18-hydroxylation appears to be unrelated to the two other types of adrenocortical hydroxylation at this position. The pathway is present to a small extent in the normal human adrenal cortex and is only moderately stimulated by ACTH. Cortisol 18-hydroxylation is markedly accentuated in two circumstances: in the aldosteronoma cell where its presence may serve to distinguish tumor from bilateral hyperplasia and in ACTH-stimulatable hyperaldosteronism where it represents the first qualitative steroid biochemical abnormality to be demonstrated and as such may be useful in diagnosis and genetic studies. The possible contribution of 18-hydroxycortisol to the severity of the clinical manifestations of mineralocorticoid excess in these two types of aldosteronism remains to be explored.
地塞米松抑制性醛固酮增多症患者的肾上腺肾小球功能。
DOI：
10.1210/jcem-53-1-158
发表时间：
1981
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Oberfield,SE;Levine,LS;Stoner,E;Chow,D;Rauh,W;Greig,F;Lee,SM;Lightner,E;Witte,M;New,MI
通讯作者：
New,MI