Brain-derived neurotrophic factor (BDNF) in children with ASD and their parents: a 3-year follow-up
Brain-derived neurotrophic factor (BDNF) in children with ASD and their parents: a 3-year follow-up
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DOI：
10.1111/acps.12872
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发表时间：
2018-05-01
影响因子：
6.7
通讯作者：
Douzenis, A.
中科院分区：
文献类型：
--
作者：
Francis, K.;Dougali, A.;Douzenis, A.
目的：一些证据表明脑源性神经营养因子（BDNF）和自闭症谱系障碍（ASD）之间可能存在关系，但研究对ASD中BDNF血清水平的研究结果不一致。方法：对45例ASD患儿（年龄30-42个月，无智力障碍，无过敏史）及正常对照组进行血清BDNF水平测定。将ASD受试者父母的BDNF血清水平与正常对照进行比较。在ASD受试者的BDNF血清水平进行了为期3年的随访，并与适应性functionalchanges.Results：BDNF血清水平被测得的ASD儿童和独立的所有主要基线特征的主题是较低的。与对照组相比，患有ASD的孩子会提高父母的BDNF水平。然而，BDNF变量的变化在时间和变化的葡萄园scores之间没有相关性被发现.Conclusions：我们的研究结果相矛盾，从最近发表的荟萃分析与年龄，ID和过敏的存在可能的影响因素。父母的数据确实指出了BDNF在ASD病理生理学中的作用。
Objective: Several lines of evidence point to a probable relationship between brain-derived neurotrophic factor (BDNF) and autism spectrum disorder (ASD), but studies have yielded inconsistent findings on the BDNF serum level in ASD. The study aimed to assess those levels in children with ASD and their families.Method: BDNF serum levels were measured in 45 ASD children without intellectual disability (ID) and allergies, age 30-42 months and age-matched normal controls. BDNF serum levels in the parents of the ASD subjects were compared to normal controls. BDNF serum levels in the ASD subjects were followed up for 3 years and correlated with adaptive functioning changes.Results: BDNF serum levels were measured to be lower in children with ASD and independent of all the major baseline characteristics of the subjects. Having a child with ASD raises the BDNF levels in parents comparing to controls. Prospectively, no correlation between the change of BDNF variables in time and the change of the Vineland scores was found.Conclusions: Our results contradict those from recent published meta-analyses with the age, the presence of ID and allergies being possible contributing factors. The parents' data indeed point to a role of BDNF in the pathophysiology of ASD.