Epitomics: global profiling of immune response to disease using protein microarrays.
Epitomics: global profiling of immune response to disease using protein microarrays.
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Epitomics：使用蛋白质微阵列对疾病免疫反应进行整体分析。
DOI：
10.1089/omi.2006.10.499
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Tainsky,MichaelA
中科院分区：
文献类型：
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作者：
Chatterjee,Madhumita;Ionan,Alexei;Draghici,Sorin;Tainsky,MichaelA
免疫系统保持对当前和过去感染的记忆，并可以通过精心制作针对肿瘤蛋白的自身抗体来感知癌症的存在。在自身免疫性疾病存在的情况下，免疫系统是一个有效的、自然的生物传感器。因此，我们通过高通量过程利用免疫系统来分离疾病特异性表位，用于诊断和治疗目的。这些克隆的疾病特异性抗原被机器人定位到蛋白质微阵列上，并用被分析对象的血清进行询问。这些阵列为个性化免疫治疗提供了抗原暴露和治疗靶点的个性化配置文件。免疫系统是终极生物传感器，优于人类能够创造的任何东西，并准备用于生物技术和生物医学。
The immune system retains memory of current and past infections and can sense the presence of cancer by elaborating autoantibodies to tumor proteins. In the presence of an autoimmune disease, the immune system is an efficient, natural biosensor. Therefore we exploit the immune system through a high-throughput process to isolate disease-specific epitopes for diagnostic and therapeutic purposes. These cloned disease-specific antigens are robotically spotted onto protein microarrays and interrogated with serum from the subjects under analyses. These arrays deliver personalized profiles of antigenic exposures and therapeutic targets for personalized immunotherapy. The immune system is the ultimate biosensor, superior to anything a human could create and ready to be exploited for biotechnology and biomedicine.