Prismatic Adaptation Changes Visuospatial Representation in the Inferior Parietal Lobule
Prismatic Adaptation Changes Visuospatial Representation in the Inferior Parietal Lobule
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DOI：
10.1523/jneurosci.3184-13.2014
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发表时间：
2014-08-27
影响因子：
5.3
通讯作者：
Clarke, Stephanie
中科院分区：
文献类型：
--
作者：
Crottaz-Herbette, Sonia;Fornari, Eleonora;Clarke, Stephanie
棱镜适应已被证明可以诱导视觉本体感受表征的重新排列并涉及顶小脑网络。我们在人类身上研究了短暂接触棱镜适应对已知涉及顶叶皮层的其他类型功能的影响程度。正常受试者在一组使用右偏棱镜进行短暂的棱镜适应之前和之后进行功能磁共振成像评估，或在另一组使用普通眼镜进行等效的测试之后进行功能磁共振成像评估。分析了三个任务的激活模式：（1）视觉检测； (2)视觉空间短期记忆； (3)言语短期记忆。当使用棱镜而不是普通眼镜时，在双侧顶下小叶中发现了与棱镜适应相关的变化。这种效应是由视觉检测任务期间的选择性变化驱动的：棱镜适应后，左侧神经活动增加，右侧顶叶减少。对视觉检测任务进行棱镜适应后激活模式的比较表明，左下顶小叶的同侧场表征显着增加，而右下顶小叶的同侧场表征显着减少。总之，短暂接触棱镜适应会在视觉检测过程中以不同的方式调节左右顶叶的激活，但在短期记忆过程中则不会。此外，顶下小叶内的视觉空间表征发生变化，右侧同侧半视野表征减少，左侧半视野表征增加，表明左侧半球占主导地位。
Prismatic adaptation has been shown to induce a realignment of visuoproprioceptive representations and to involve parietocerebellar networks. We have investigated in humans how far other types of functions known to involve the parietal cortex are influenced by a brief exposure to prismatic adaptation. Normal subjects underwent an fMRI evaluation before and after a brief session of prismatic adaptation using rightward deviating prisms for one group or after an equivalent session using plain glasses for the other group. Activation patterns to three tasks were analyzed: (1) visual detection; (2) visuospatial short-term memory; and (3) verbal short-term memory. The prismatic adaptation-related changes were found bilaterally in the inferior parietal lobule when prisms, but not plain glasses, were used. This effect was driven by selective changes during the visual detection task: an increase in neural activity was induced on the left and a decrease on the right parietal side after prismatic adaptation. Comparison of activation patterns after prismatic adaptation on the visual detection task demonstrated a significant increase of the ipsilateral field representation in the left inferior parietal lobule and a significant decrease in the right inferior parietal lobule. In conclusion, a brief exposure to prismatic adaptation modulates differently left and right parietal activation during visual detection but not during short-term memory. Furthermore, the visuospatial representation within the inferior parietal lobule changes, with a decrease of the ipsilateral hemifield representation on the right and increase on the left side, suggesting thus a left hemispheric dominance.