Neural correlates of a reversal learning task with an affectively neutral baseline: An event-related fMRI study
Neural correlates of a reversal learning task with an affectively neutral baseline: An event-related fMRI study
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DOI：
10.1016/j.neuroimage.2005.02.009
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发表时间：
2005-06-01
期刊：
影响因子：
5.7
通讯作者：
Veltman, DJ
中科院分区：
文献类型：
--
作者：
Remijnse, PL;Nielen, MMA;Veltman, DJ
再激励学习可以在概念上被分解为获得刺激-强化关联，并且随后通过在刺激-强化偶然性逆转时切换到新的关联来改变行为（即，情感转换）。先前的影像学研究发现腹外侧和眶额皮质（OFC）的区域参与这两个子过程。然而，这些研究不包含情感中立的基线，这使得无法充分评估奖励、惩罚和情感转换的主要影响。我们的目标是确定这些主要效应的神经基质，以及奖励和惩罚的共同和可分离区域。此外，我们的目标是区分刺激-惩罚关联和情感转换，即，来评估情感转换为此，我们实施了一个反向学习任务，情感中性基线条件，匹配的实验任务，在视觉复杂性和运动需求。有趣的是，我们发现背外侧前额叶皮层（DLPFC）和前PFC参与情感转换，这一发现以前没有报道过我们的知识。在这些领域的增强反应可能代表他们参与认知集转移本身无关的情感环境中的逆转学习设计。此外，眶额皮层、岛叶和内侧前额叶皮层也参与了情感转换。左内侧和外侧眶额皮层是反馈处理的共同区域，而左腹侧纹状体和左外侧眶额皮层分别被奖励和惩罚特异性激活。这些结果扩展了我们对人类逆转学习神经基础的理解。(c)2005年爱思唯尔公司All rights reserved.
Reversal learning may conceptually be dissected into acquiring stimulus-reinforcement associations and subsequently altering behavior by switching to new associations as stimulus-reinforcement contingencies reverse (i.e., affective switching). Previous imaging studies have found regions of the ventrolateral and orbitofrontal cortex (OFC) to be involved in both subprocesses. However, these studies did not contain an affectively neutral baseline, which precluded adequate assessment of main effects of reward, punishment, and affective switching. We aimed to determine the neural substrate of these main effects, and of common and dissociable regions for reward and punishment. Furthermore, we aimed to discriminate between stimulus-punishment association and affective switching, i.e., to assess affective switching proper. To this end, we implemented a reversal learning task with an affectively neutral baseline condition that matched the experimental task in visual complexity and motor demands. Interestingly, we found dorsolateral prefrontal cortex (DLPFC) and anterior PFC to be engaged in affective switching, a finding that has not been reported before to our knowledge. Enhanced responses in these areas may represent their involvement in cognitive set shifting per se unrelated to the affective context in a reversal learning design. In addition, OFC, insular and medial prefrontal cortex regions were involved in affective switching. Left medial and lateral OFC were shown to be common areas for feedback processing, whereas left ventral striatum and left lateral OFC were specifically activated by reward and punishment, respectively. These results extend our understanding of the neural substrate of reversal learning in humans. (c) 2005 Elsevier Inc. All rights reserved.