Y-chromosome O3 Haplogroup Diversity in Sino-Tibetan Populations Reveals Two Migration Routes into the Eastern Himalayas
Y-chromosome O3 Haplogroup Diversity in Sino-Tibetan Populations Reveals Two Migration Routes into the Eastern Himalayas
复制标题
汉藏人群 Y 染色体 O3 单倍群多样性揭示了喜马拉雅东部的两条迁徙路线
DOI：
10.1111/j.1469-1809.2011.00690.x
复制
发表时间：
2012-01-01
影响因子：
1.9
通讯作者：
Li, Hui
中科院分区：
文献类型：
--
作者：
Kang, Longli;Lu, Yan;Li, Hui
东喜马拉雅山脉位于南入口附近，早期现代人通过该入口扩展到东亚。因此，该地区的遗传结构在东亚起源研究中具有重要意义。然而，对该地区汉藏族(罗巴族和邓族)的遗传学研究却很少。在这里，我们分析了这两个群体的Y染色体多样性。罗巴人拥有D、N、O、J、Q和R单倍群，表明基因来自藏族以及欧亚大陆西部和北部。邓氏人表现出O、D、N和C单倍群，与东部的大多数汉藏族群体相似。汉藏群体中优势单倍群O_3的短串联重复序列(STR)多样性表明，罗巴族与藏族遗传关系较近，邓族与羌族亲缘关系较近。羌族具有最大的汉藏族人口多样性，支持这一群体是家族中年龄最大的观点。多样性最低的出现在喜马拉雅山脉东部，这表明该地区是汉藏族人口扩张的终点。因此，我们已经表明，具有单倍群O3的种群至少通过两条路线进入东喜马拉雅山脉。
The eastern Himalayas are located near the southern entrance through which early modern humans expanded into East Asia. The genetic structure in this region is therefore of great importance in the study of East Asian origins. However, few genetic studies have been performed on the Sino-Tibetan populations (Luoba and Deng) in this region. Here, we analyzed the Y-chromosome diversity of the two populations. The Luoba possessed haplogroups D, N, O, J, Q, and R, indicating gene flow from Tibetans, as well as the western and northern Eurasians. The Deng exhibited haplogroups O, D, N, and C, similar to most Sino-Tibetan populations in the east. Short tandem repeat (STR) diversity within the dominant haplogroup O3 in Sino-Tibetan populations showed that the Luoba are genetically close to Tibetans and the Deng are close to the Qiang. The Qiang had the greatest diversity of Sino-Tibetan populations, supporting the view of this population being the oldest in the family. The lowest diversity occurred in the eastern Himalayas, suggesting that this area was an endpoint for the expansion of Sino-Tibetan people. Thus, we have shown that populations with haplogroup O3 moved into the eastern Himalayas through at least two routes.