Mapping Phylogenetic Trees to Reveal Distinct Patterns of Evolution
Mapping Phylogenetic Trees to Reveal Distinct Patterns of Evolution
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DOI：
10.1093/molbev/msw124
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发表时间：
2016-10-01
影响因子：
10.7
通讯作者：
Colijn, Caroline
中科院分区：
文献类型：
--
作者：
Kendall, Michelle;Colijn, Caroline
进化关系经常用系统发育树来描述，但许多领域的一个中心障碍是难以解释包含冲突的系统发育信号的数据。我们提出了一种基于度量的方法来比较树，该方法提取嵌入在数据中的不同的替代进化关系。我们在最近对变色蜥蜴的研究中证明了系统发育不确定性的检测和解决，从而导致了关于它们进化关系的替代假设。我们使用我们的方法比较源自埃博拉病毒不同基因的树，发现 VP30 基因具有独特的系统发育特征，由深分支结构不同的三种替代方案组成。
Evolutionary relationships are frequently described by phylogenetic trees, but a central barrier in many fields is the difficulty of interpreting data containing conflicting phylogenetic signals. We present a metric-based method for comparing trees which extracts distinct alternative evolutionary relationships embedded in data. We demonstrate detection and resolution of phylogenetic uncertainty in a recent study of anole lizards, leading to alternate hypotheses about their evolutionary relationships. We use our approach to compare trees derived from different genes of Ebolavirus and find that the VP30 gene has a distinct phylogenetic signature composed of three alternatives that differ in the deep branching structure.