The P300 brain potential is reduced in smokers
The P300 brain potential is reduced in smokers
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DOI：
10.1007/s002130000387
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发表时间：
2000-05-01
影响因子：
3.4
通讯作者：
Rohrbaugh, JW
中科院分区：
文献类型：
--
作者：
Anokhin, AP;Vedeniapin, AB;Rohrbaugh, JW
基本原理：吸烟是最普遍的物质滥用类型，但其生物行为病因学知之甚少。识别吸烟者和非吸烟者的神经认知功能的基本特征的差异可能有助于阐明烟草依赖的机制。目标.本研究评估了吸烟状况和事件相关电位（ERP）的P300成分之间的关系，同时控制了潜在的混杂因素，如酗酒，药物滥用和精神病理学。研究方法：在顶叶中部测量了905名吸烟者、463名戒烟者和979名从不吸烟者的ERP反应。结果：目前吸烟者的P300振幅显著低于从不吸烟者。戒烟者与从不吸烟者没有显著差异。P300降低也与酗酒、药物依赖和酗酒家庭密度有关。然而，在控制吸烟后，只有酗酒的家庭密度仍然是P300振幅的显着预测。结论：结果表明，吸烟状态对P300振幅有显著影响，这与酗酒家族史有关，并表明（1）长期吸烟可能会导致脑功能的可逆变化，或（2）P300降低可能是尼古丁依赖风险的标志。
Rationale: Tobacco smoking is the most prevalent type of substance abuse, yet its biobehavioral etiology is little understood. Identification of differences between smokers and non-smokers on basic characteristics of neurocognitive functioning may help to elucidate the mechanisms of tobacco dependence. Objectives. This study assessed the relationship between smoking status and the P300 component of event-related potential (ERP) while controlling for potential confounders such as alcoholism, drug abuse, and psychopathology. Methods: The ERP responses elicited by a visual oddball task were measured at the mid-parietal site in 905 current smokers, 463 ex-smokers, and 979 never smokers. Results: P300 amplitude was significantly lower in current cigarette smokers compared to never-smokers. Ex-smokers did not differ significantly from never-smokers. P300 reduction was also associated with alcoholism, drug dependence, and family density of alcoholism. However, after controlling for smoking, only family density of alcoholism remained a significant predictor of P300 amplitude. Conclusions: The results indicate a significant effect of smoking status on P300 amplitude which is additive to family history of alcoholism and suggest that either (1) long-term tobacco smoking may produce a reversible change in brain function, or (2) reduced P300 may be a marker of risk for nicotine dependence.