Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
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DOI：
10.1038/bjc.1977.1
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发表时间：
1977-01
影响因子：
8.8
通讯作者：
Smith PG
中科院分区：
文献类型：
--
作者：
Peto R;Pike MC;Armitage P;Breslow NE;Cox DR;Howard SV;Mantel N;McPherson K;Peto J;Smith PG
本报告第一部分载于上一期（Br. J. Cancer（1976）34，585），并讨论了随机临床试验的设计。第二部分描述了随机临床试验的有效分析方法，在这些试验中，我们希望比较不同患者组的生存期（或直到某些其他不良事件首次发生的时间）。它的目的是使没有统计学培训的医生使用寿命表，对数秩检验和回顾性分层分析这些数据本身，或者，当这样的分析，以欣赏他们更严格，但讨论也可能是感兴趣的统计学家谁还没有专门从事临床试验分析。
Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and discussed the design of randomized clinical trials. Part II now describes efficient methods of analysis of randomized clinical trials in which we wish to compare the duration of survival (or the time until some other untoward event first occurs) among different groups of patients. It is intended to enable physicians without statistical training either to analyse such data themselves using life tables, the logrank test and retrospective stratification, or, when such analyses are presented, to appreciate them more critically, but the discussion may also be of interest to statisticians who have not yet specialized in clinical trial analyses.