Multifunctional asymmetric catalysis.
Multifunctional asymmetric catalysis.
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DOI：
10.1007/978-3-662-04042-3_11
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发表时间：
2001-05
影响因子：
1.7
通讯作者：
M. Shibasaki
中科院分区：
文献类型：
--
作者：
M. Shibasaki
催化不对称反应的发展是有机化学领域的主要研究领域之一。到目前为止，已经报道了一些手性催化剂，其中一些表现出比酶的催化效率高得多的天然催化剂(Herrmann和Cornils 1996；Noyori 1994；Ojima 1994；Bosnich 1986；Morison 1985)。然而，大多数合成的不对称催化剂在对映体选择性或化学产率方面表现出有限的活性。人工合成的不对称催化剂与酶的主要区别在于，前者在分子间反应中只激活底物的一侧，而后者不仅激活底物的两侧，而且还可以控制底物的取向。如果这种协同合作能够在合成不对称催化中实现，这一概念将为不对称合成开辟一个新的领域，并将有广泛的应用前景。本文综述了由具有Lewis酸性和Brpnsted碱性的络合物促进的两类不对称双中心催化剂。
The development of catalytic asymmetric reactions is one of the major areas of research in the field of organic chemistry. So far, a number of chiral catalysts have been reported, and some of them have exhibited a much higher catalytic efficiency than enzymes, which are natural catalysts (Herrmann and Cornils 1996; Noyori 1994; Ojima 1994; Bosnich 1986; Morrison 1985). Most of the synthetic asymmetric catalysts, however, show limited activity in terms of either enantioselectivity or chemical yields. The major difference between synthetic asymmetric catalysts and enzymes is that the former activate only one side of the substrate in an intermolecular reaction, whereas the latter not only activate both sides of the substrate but can also control the orientation of the substrate. If this kind of synergistic cooperation can be realized in synthetic asymmetric catalysis, the concept will open up a new field in asymmetric synthesis, and a wide range of applications may well ensue. This minireview covers two types of asymmetric two-center catalyses promoted by complexes showing Lewis acidity and Brpnsted basicity