Antisynthetase syndrome associated with sarcoidosis
Antisynthetase syndrome associated with sarcoidosis
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DOI：
10.2169/internalmedicine.45.1772
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发表时间：
2006-01-01
影响因子：
1.2
通讯作者：
Moriguchi, Masato
中科院分区：
文献类型：
--
作者：
Asanuma, Yu;Koichihara, Reiko;Moriguchi, Masato
一位30岁的男性主诉多关节痛和疲劳。临床表现和实验室检查包括肌炎、多发性关节炎、间质性肺炎、雷诺现象、机械手和抗PL-7抗体（苏氨酰-tRNA合成酶抗体）。所有这些体征均符合抗合成酶综合征。他的胸片显示双侧肺门淋巴结肿大。纵隔淋巴结和肌肉活检标本显示非干酪化上皮样细胞肉芽肿。肺组织学显示非特异性间质性肺炎。诊断为结节病相关的抗合成酶综合征。间质性肺炎在这个病人反应良好，大剂量皮质类固醇治疗。
A 30-year-old man complained of polyarthralgia and fatigue. The clinical findings and laboratory data included myositis, polyarthritis, interstitial pneumonia, Raynaud's phenomenon, mechanic's hand, and anti PL-7 antibody (threonyl-tRNA synthetase antibody). All of these signs were consistent with antisynthetase syndrome. His chest radiograph revealed bilateral hilar lymphadenopathy. Biopsy specimens from his mediastinal lymph node and muscle showed noncaseating epithelioid cell granulomas. Lung histology revealed nonspecific interstitial pneumonia. Antisynthetase syndrome associated with sarcoidosis was diagnosed. Interstitial pneumonia in this patient responded well to high-dose corticosteroid therapy.