Expedited strategies for the restoration of bone
Expedited strategies for the restoration of bone
复制标题
骨骼恢复的快速策略
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
R. Porter
中科院分区：
文献类型：
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作者：
C. Evans;V. Glatt;Fangjun Liu;J. Wells;E. Ferreira;M. Vrahas;M. Harris;A. Ivković;R. Porter
简介：我们正试图设计用于修复和再生结缔组织的快速技术，以减少对细胞培养、生物反应器和其他昂贵组件的需求[1]。对于骨愈合，基本策略旨在开发术中程序，其中组织在一次手术中被采集、修改并返回到个体。我们已经集中在使用骨髓，脂肪和肌肉作为组织，可以很容易地收获，并含有骨祖细胞。基因转移是一种方法，其中一旦组织返回到身体，可以启动和维持驻留祖细胞的成骨分化。在这里，我们描述了使用肌肉和骨髓作为骨祖细胞来源获得的数据。
INTRODUCTION: We are trying to devise expedited technologies for the repair and regeneration of connective tissues that obviate the need for cell culture, bioreactors and other expensive components [1]. For bone healing, a basic strategy aims to develop intra-operative procedures in which tissue is harvested, modified and returned to the individual in one surgery. We have concentrated on the use of bone marrow, fat and muscle as tissues that can be readily harvested, and which contain osteoprogenitor cells. Gene transfer is one way in which the osteogenic differentiation of the resident progenitor cells can be initiated and sustained once the tissues are retuned to the body. Here we describe data obtained using muscle and bone marrow as sources of osteoprogenitors.