Modifying oligoalanine conformation by replacement of amide to ester linkage
Modifying oligoalanine conformation by replacement of amide to ester linkage
复制标题
通过将酰胺键替换为酯键来修饰寡丙氨酸构象
作者：
Hongen Takahiro;Taniguchi Tohru;Monde Kenji
寡聚（乳酸）是短寡聚丙氨酸序列的酯类似物，并采用刚性左手螺旋结构。在这项研究中，寡（乳酸）被纳入寡丙氨酸序列和它们的构象进行了研究，振动圆二色性和电子圆二色性光谱。结果表明，这些序列中的寡聚（乳酸）部分保持了左手螺旋，并增加了寡聚丙氨酸部分形成左手聚脯氨酸II型样螺旋的构象倾向。同时研究了低聚乳酸部分手性对低聚丙氨酸构象的重要性。在这项研究中获得的结果应该是有用的开发含酯的寡肽，功能比正常肽更好。
Oligo(lactic acid) is an ester‐analogue of short oligoalanine sequence and adopts a rigid left‐handed helical structure. In this study, oligo(lactic acid) was incorporated into oligoalanine sequences and their conformations were studied by vibrational circular dichroism and electronic circular dichroism spectroscopy. The results suggested that oligo(lactic acid) moiety in these sequences maintains a left‐handed helix and increases the conformational propensity of the oligoalanine moiety to form a left‐handed polyproline type II‐like helix. The importance of the chirality of oligo(lactic acid) moiety for the oligoalanine conformation was also studied. The results obtained in this study should be useful in developing ester‐containing oligopeptides that function better than normal peptides.