Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins
Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins
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DOI：
10.1136/hrt.2006.089359
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发表时间：
2007-01-01
期刊：
影响因子：
5.7
通讯作者：
Chen, S-A
中科院分区：
文献类型：
--
作者：
Chang, S-L;Chen, Y-C;Chen, S-A
背景：心房颤动通常与肺静脉扩张有关。拉伸具有力电效应。目的：探讨拉伸是否能增加肺静脉的致心律失常活性。方法：记录拉伸前后兔肺静脉跨膜动作电位(100 mg和300 mg)。结果：牵张力(0、100和300 mg)依赖地增加自发活动的发生率(22%、48%和83%；p<；0.05)，自发活动的平均放电率(1.7(0.2)、2.1(0.3)和3(0.2)Hz；p<；0.05)和早期后去极化的发生率(9%、26%和61%；p<；0.05)；延迟后除极(0%、4%和30%；p<；0.05)。在300 mg牵张后出现自发活动的7组大鼠中，Gd(1、3和10mU·m o l/L)使自发活动发生率分别降低43%、29%和14%(p<；0.05)，放电频率从2.9(0.1)Hz分别降低到0.8(0.4)、0.3(0.1)和0.1(0.1)Hz(p<；0.05)。链霉素(10和40 mU·m o l/L)使自主活动发生率分别降低71%和29%(p<；0.05)，放电频率分别从2.9(0.1)Hz降低到1.6(0.4)和0.5(0.3)Hz(p<；0.05)。结论：牵张是影响肺静脉电活动的重要因素。牵张引起的肺静脉致心律失常活动可能与房颤的发生有关。
Background: Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects.Objective: To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins.Methods: The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch ( 100 and 300 mg). Gadolinium and streptomycin ( stretch-activated ion channel blockers) were each perfused into the pulmonary veins under a 300-mg stretch.Results: Stretch ( 0, 100 and 300 mg) force dependently increased the incidence of spontaneous activity ( 22%, 48% and 83%; p < 0.05), mean ( standard deviation ( SD)) firing rates of spontaneous activity ( 1.7 ( 0.2), 2.1 ( 0.3) and 3 ( 0.2) Hz; p < 0.05) and incidence of early post-depolarisations ( 9%, 26% and 61%; p < 0.05) and delayed post-depolarisations ( 0%, 4% and 30%; p < 0.05) in 23 pulmonary veins. In the seven preparations with spontaneous activity after the 300-mg stretch, gadolinium ( 1, 3 and 10 mu mol/l) decreased the incidence of spontaneous activity by 43%, 29% and 14%, respectively ( p < 0.05), and decreased the firing rate from 2.9 ( 0.1) Hz to 0.8 ( 0.4), 0.3 ( 0.1) and 0.1 ( 0.1) Hz, respectively ( p < 0.05). Streptomycin ( 10 and 40 mu mol/l) decreased the incidence of spontaneous activity by 71% and 29%, respectively ( p < 0.05), and decreased the firing rate from 2.9 ( 0.1) Hz to 1.6 ( 0.4) and 0.5 ( 0.3) Hz, respectively ( p < 0.05).Conclusion: Stretch is an important factor in the electrical activity of the pulmonary vein. Stretch-induced arrhythmogenic activity of the pulmonary vein may contribute to the genesis of atrial fibrillation.