New twists in actin-microtubule interactions.
New twists in actin-microtubule interactions.
复制标题
DOI：
10.1091/mbc.e19-09-0491
复制
发表时间：
2021-02-01
影响因子：
3.3
通讯作者：
Henty-Ridilla JL
中科院分区：
文献类型：
--
作者：
Pimm ML;Henty-Ridilla JL
肌动蛋白丝和微管是细胞骨架聚合物，参与许多重要的细胞功能，包括分裂、形态发生、吞噬作用和运动。尽管人们一直认为肌动蛋白丝和微管网络在定位、结构和功能上是不同的，但越来越多的证据表明，这些元素是通过对任一聚合物敏感的复杂机制精心设计的。许多介导肌动蛋白-微管相互作用的蛋白质和细胞信号已经被识别。然而，这些调节剂的影响通常单独使用肌动蛋白丝或微管聚合物来评估，独立于其他系统。此外，协调肌动蛋白-微管相互作用的非常规模式和调节器仍在被发现。 在这里，我们研究了肌动蛋白-微管串扰的几种方法，重点是两个聚合物系统之间的分子联系及其高阶相互作用。
Actin filaments and microtubules are cytoskeletal polymers that participate in many vital cell functions including division, morphogenesis, phagocytosis, and motility. Despite the persistent dogma that actin filament and microtubule networks are distinct in localization, structure, and function, a growing body of evidence shows that these elements are choreographed through intricate mechanisms sensitive to either polymer. Many proteins and cellular signals that mediate actin–microtubule interactions have already been identified. However, the impact of these regulators is typically assessed with actin filament or microtubule polymers alone, independent of the other system. Further, unconventional modes and regulators coordinating actin–microtubule interactions are still being discovered. Here we examine several methods of actin–microtubule crosstalk with an emphasis on the molecular links between both polymer systems and their higher-order interactions.