Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
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DOI:
10.1038/ng.3698
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发表时间:
2016-12
期刊:
影响因子:
30.8
通讯作者:
Mills MC
中科院分区:
文献类型:
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作者:
Barban N;Jansen R;de Vlaming R;Vaez A;Mandemakers JJ;Tropf FC;Shen X;Wilson JF;Chasman DI;Nolte IM;Tragante V;van der Laan SW;Perry JR;Kong A;BIOS Consortium;Ahluwalia TS;Albrecht E;Yerges-Armstrong L;Atzmon G;Auro K;Ayers K;Bakshi A;Ben-Avraham D;Berger K;Bergman A;Bertram L;Bielak LF;Bjornsdottir G;Bonder MJ;Broer L;Bui M;Barbieri C;Cavadino A;Chavarro JE;Turman C;Concas MP;Cordell HJ;Davies G;Eibich P;Eriksson N;Esko T;Eriksson J;Falahi F;Felix JF;Fontana MA;Franke L;Gandin I;Gaskins AJ;Gieger C;Gunderson EP;Guo X;Hayward C;He C;Hofer E;Huang H;Joshi PK;Kanoni S;Karlsson R;Kiechl S;Kifley A;Kluttig A;Kraft P;Lagou V;Lecoeur C;Lahti J;Li-Gao R;Lind PA;Liu T;Makalic E;Mamasoula C;Matteson L;Mbarek H;McArdle PF;McMahon G;Meddens SF;Mihailov E;Miller M;Missmer SA;Monnereau C;van der Most PJ;Myhre R;Nalls MA;Nutile T;Kalafati IP;Porcu E;Prokopenko I;Rajan KB;Rich-Edwards J;Rietveld CA;Robino A;Rose LM;Rueedi R;Ryan KA;Saba Y;Schmidt D;Smith JA;Stolk L;Streeten E;Tönjes A;Thorleifsson G;Ulivi S;Wedenoja J;Wellmann J;Willeit P;Yao J;Yengo L;Zhao JH;Zhao W;Zhernakova DV;Amin N;Andrews H;Balkau B;Barzilai N;Bergmann S;Biino G;Bisgaard H;Bønnelykke K;Boomsma DI;Buring JE;Campbell H;Cappellani S;Ciullo M;Cox SR;Cucca F;Toniolo D;Davey-Smith G;Deary IJ;Dedoussis G;Deloukas P;van Duijn CM;de Geus EJ;Eriksson JG;Evans DA;Faul JD;Sala CF;Froguel P;Gasparini P;Girotto G;Grabe HJ;Greiser KH;Groenen PJ;de Haan HG;Haerting J;Harris TB;Heath AC;Heikkilä K;Hofman A;Homuth G;Holliday EG;Hopper J;Hyppönen E;Jacobsson B;Jaddoe VW;Johannesson M;Jugessur A;Kähönen M;Kajantie E;Kardia SL;Keavney B;Kolcic I;Koponen P;Kovacs P;Kronenberg F;Kutalik Z;La Bianca M;Lachance G;Iacono WG;Lai S;Lehtimäki T;Liewald DC;LifeLines Cohort Study;Lindgren CM;Liu Y;Luben R;Lucht M;Luoto R;Magnus P;Magnusson PK;Martin NG;McGue M;McQuillan R;Medland SE;Meisinger C;Mellström D;Metspalu A;Traglia M;Milani L;Mitchell P;Montgomery GW;Mook-Kanamori D;de Mutsert R;Nohr EA;Ohlsson C;Olsen J;Ong KK;Paternoster L;Pattie A;Penninx BW;Perola M;Peyser PA;Pirastu M;Polasek O;Power C;Kaprio J;Raffel LJ;Räikkönen K;Raitakari O;Ridker PM;Ring SM;Roll K;Rudan I;Ruggiero D;Rujescu D;Salomaa V;Schlessinger D;Schmidt H;Schmidt R;Schupf N;Smit J;Sorice R;Spector TD;Starr JM;Stöckl D;Strauch K;Stumvoll M;Swertz MA;Thorsteinsdottir U;Thurik AR;Timpson NJ;Tung JY;Uitterlinden AG;Vaccargiu S;Viikari J;Vitart V;Völzke H;Vollenweider P;Vuckovic D;Waage J;Wagner GG;Wang JJ;Wareham NJ;Weir DR;Willemsen G;Willeit J;Wright AF;Zondervan KT;Stefansson K;Krueger RF;Lee JJ;Benjamin DJ;Cesarini D;Koellinger PD;den Hoed M;Snieder H;Mills MC
The genetic architecture of human reproductive behavior – age at first birth (AFB) and number of children ever born (NEB) – has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified and the underlying mechanisms of AFB and NEB are poorly understood. We report the largest genome-wide association study to date of both sexes including 251,151 individuals for AFB and 343,072 for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study, and four additional loci in a gene-based effort. These loci harbor genes that are likely to play a role – either directly or by affecting non-local gene expression – in human reproduction and infertility, thereby increasing our understanding of these complex traits.
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影响因子:
30.8
作者:
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者:
Neale, Benjamin M.
DOI:
10.1093/bioinformatics/btu848
发表时间:
2015-05-01
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
作者:
Euesden J;Lewis CM;O'Reilly PF
通讯作者:
O'Reilly PF
影响因子:
7
作者:
Boyle AP;Hong EL;Hariharan M;Cheng Y;Schaub MA;Kasowski M;Karczewski KJ;Park J;Hitz BC;Weng S;Cherry JM;Snyder M
通讯作者:
Snyder M
影响因子:
3.9
作者:
Franklin, RB;Ma, J;Costello, LC
通讯作者:
Costello, LC
影响因子:
30.8
作者:
通讯作者:
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