Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
复制标题

DOI:
10.1038/ng.3698
复制
发表时间:
2016-12
期刊:
影响因子:
30.8
通讯作者:
Mills MC
Mills MC
中科院分区:
生物学1区
文献类型:
--
作者:
Barban N;Jansen R;de Vlaming R;Vaez A;Mandemakers JJ;Tropf FC;Shen X;Wilson JF;Chasman DI;Nolte IM;Tragante V;van der Laan SW;Perry JR;Kong A;BIOS Consortium;Ahluwalia TS;Albrecht E;Yerges-Armstrong L;Atzmon G;Auro K;Ayers K;Bakshi A;Ben-Avraham D;Berger K;Bergman A;Bertram L;Bielak LF;Bjornsdottir G;Bonder MJ;Broer L;Bui M;Barbieri C;Cavadino A;Chavarro JE;Turman C;Concas MP;Cordell HJ;Davies G;Eibich P;Eriksson N;Esko T;Eriksson J;Falahi F;Felix JF;Fontana MA;Franke L;Gandin I;Gaskins AJ;Gieger C;Gunderson EP;Guo X;Hayward C;He C;Hofer E;Huang H;Joshi PK;Kanoni S;Karlsson R;Kiechl S;Kifley A;Kluttig A;Kraft P;Lagou V;Lecoeur C;Lahti J;Li-Gao R;Lind PA;Liu T;Makalic E;Mamasoula C;Matteson L;Mbarek H;McArdle PF;McMahon G;Meddens SF;Mihailov E;Miller M;Missmer SA;Monnereau C;van der Most PJ;Myhre R;Nalls MA;Nutile T;Kalafati IP;Porcu E;Prokopenko I;Rajan KB;Rich-Edwards J;Rietveld CA;Robino A;Rose LM;Rueedi R;Ryan KA;Saba Y;Schmidt D;Smith JA;Stolk L;Streeten E;Tönjes A;Thorleifsson G;Ulivi S;Wedenoja J;Wellmann J;Willeit P;Yao J;Yengo L;Zhao JH;Zhao W;Zhernakova DV;Amin N;Andrews H;Balkau B;Barzilai N;Bergmann S;Biino G;Bisgaard H;Bønnelykke K;Boomsma DI;Buring JE;Campbell H;Cappellani S;Ciullo M;Cox SR;Cucca F;Toniolo D;Davey-Smith G;Deary IJ;Dedoussis G;Deloukas P;van Duijn CM;de Geus EJ;Eriksson JG;Evans DA;Faul JD;Sala CF;Froguel P;Gasparini P;Girotto G;Grabe HJ;Greiser KH;Groenen PJ;de Haan HG;Haerting J;Harris TB;Heath AC;Heikkilä K;Hofman A;Homuth G;Holliday EG;Hopper J;Hyppönen E;Jacobsson B;Jaddoe VW;Johannesson M;Jugessur A;Kähönen M;Kajantie E;Kardia SL;Keavney B;Kolcic I;Koponen P;Kovacs P;Kronenberg F;Kutalik Z;La Bianca M;Lachance G;Iacono WG;Lai S;Lehtimäki T;Liewald DC;LifeLines Cohort Study;Lindgren CM;Liu Y;Luben R;Lucht M;Luoto R;Magnus P;Magnusson PK;Martin NG;McGue M;McQuillan R;Medland SE;Meisinger C;Mellström D;Metspalu A;Traglia M;Milani L;Mitchell P;Montgomery GW;Mook-Kanamori D;de Mutsert R;Nohr EA;Ohlsson C;Olsen J;Ong KK;Paternoster L;Pattie A;Penninx BW;Perola M;Peyser PA;Pirastu M;Polasek O;Power C;Kaprio J;Raffel LJ;Räikkönen K;Raitakari O;Ridker PM;Ring SM;Roll K;Rudan I;Ruggiero D;Rujescu D;Salomaa V;Schlessinger D;Schmidt H;Schmidt R;Schupf N;Smit J;Sorice R;Spector TD;Starr JM;Stöckl D;Strauch K;Stumvoll M;Swertz MA;Thorsteinsdottir U;Thurik AR;Timpson NJ;Tung JY;Uitterlinden AG;Vaccargiu S;Viikari J;Vitart V;Völzke H;Vollenweider P;Vuckovic D;Waage J;Wagner GG;Wang JJ;Wareham NJ;Weir DR;Willemsen G;Willeit J;Wright AF;Zondervan KT;Stefansson K;Krueger RF;Lee JJ;Benjamin DJ;Cesarini D;Koellinger PD;den Hoed M;Snieder H;Mills MC

文献摘要

参考文献

被引文献

相似文献

人类生殖行为的遗传结构——首次生育年龄(AFB)和生育子女数量(NEB)——与健康、人类发育、不孕症和神经精神疾病的风险有着密切的关系。然而,已经确定的遗传位点很少,并且对AFB和NEB的潜在机制知之甚少。我们报告了迄今为止最大规模的两性全基因组关联研究,包括251,151个AFB个体和343,072个NEB个体。我们在基于snp的全基因组关联研究中发现了12个与AFB和/或NEB显著相关的独立位点,并在基于基因的研究中发现了另外4个位点。这些基因座可能直接或通过影响非局部基因表达在人类生殖和不育中发挥作用,从而增加了我们对这些复杂性状的理解。
The genetic architecture of human reproductive behavior – age at first birth (AFB) and number of children ever born (NEB) – has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified and the underlying mechanisms of AFB and NEB are poorly understood. We report the largest genome-wide association study to date of both sexes including 251,151 individuals for AFB and 343,072 for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study, and four additional loci in a gene-based effort. These loci harbor genes that are likely to play a role – either directly or by affecting non-local gene expression – in human reproduction and infertility, thereby increasing our understanding of these complex traits.
DOI: 10.1038/ng.3211
发表时间: 2015-03
期刊: NATURE GENETICS
影响因子: 30.8
作者:
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者: Neale, Benjamin M.
DOI: 10.1093/bioinformatics/btu848
发表时间: 2015-05-01
期刊: Bioinformatics (Oxford, England)
影响因子: --
作者:
Euesden J;Lewis CM;O'Reilly PF
通讯作者: O'Reilly PF
DOI: 10.1101/gr.137323.112
发表时间: 2012-09
期刊: Genome research
影响因子: 7
作者:
Boyle AP;Hong EL;Hariharan M;Cheng Y;Schaub MA;Kasowski M;Karczewski KJ;Park J;Hitz BC;Weng S;Cherry JM;Snyder M
通讯作者: Snyder M
DOI: 10.1016/s0162-0134(03)00249-6
发表时间: 2003-08-01
影响因子: 3.9
作者:
Franklin, RB;Ma, J;Costello, LC
通讯作者: Costello, LC
DOI: 10.1038/ng.714
发表时间: 2010-12
期刊: Nature genetics
影响因子: 30.8
作者:
通讯作者: --