Normal-weight obese syndrome: early inflammation?
Normal-weight obese syndrome: early inflammation?
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DOI：
10.1093/ajcn/85.1.40
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发表时间：
2007-01-01
影响因子：
7.1
通讯作者：
Di Renzo, Laura
中科院分区：
文献类型：
--
作者：
De Lorenzo, Antonino;Del Gobbo, Vera;Di Renzo, Laura
背景：在肥胖受试者中，脂肪量是促炎细胞因子的重要来源。我们发现了一种新的综合征--正常体重肥胖（NWO）综合征--发生在体重和体重指数正常的女性中，但其脂肪量超过其总体重的30%，并且其发生肥胖相关疾病的风险可能增加。目的：本研究的目的是验证NWO妇女的特征是早期炎症的假设，与体脂量有关，设计：20名NWO、20名肥胖前期和20名健康（非肥胖）、年龄匹配的白色意大利女性进行了研究。人体测量变量和血浆浓度的促炎细胞因子和心血管疾病（CVD）的危险因素进行了测量和groups.Results：血浆值和身体成分的措施之间的preobese-obese和nonobese妇女显着不同。NWO组和非肥胖组在体重、实验室检查值或CVD危险因素方面无显著差异。与NWO妇女的浓度相比，非肥胖组的白细胞介素（IL）-1 α、IL- 1 β、IL-6、IL-8和TNF-α的血浆浓度显著较低，而肥胖前期肥胖组的血浆浓度显著较高。IL-6和TNF-α浓度与NWO women.Conclusions中的脂肪质量分布有关：促炎细胞因子可被视为NWO妇女肥胖、CVD和代谢综合征风险的重要预后指标。
Background: In obese subjects, the adipose mass represents an important source of proinflammatory cytokines. We have identified a new syndrome-the normal-weight obese (NWO) syndrome-in women with normal weight and body mass index but whose fat mass is > 30% of their total body weight and whose risk of developing obesity-related diseases is likely increased.Objective: The aim of the present study was to verify the hypothesis that NWO women are characterized by early inflammation, related to body fat mass, and that their plasma proinflammatory cytokine concentrations are greater than those of nonobese women.Design: Twenty NWO, 20 preobese-obese, and 20 healthy (nonobese), age-matched white Italian women were studied. Anthropometric variables and plasma concentrations of proinflammatory cytokines and cardiovascular disease (CVD) risk factors were measured and compared between groups.Results: Plasma values and body-composition measures were significantly different between the preobese-obese and nonobese women. No significant differences in body weight, laboratory values, or CVD risk factors were found between the NWO and nonobese groups. Compared with concentrations in the NWO women, plasma concentrations of interleukin (IL)- 1 alpha, IL- 1 beta, IL-6, IL-8, and TNF-alpha were significantly lower in the nonobese group and were significantly greater in the preobese-obese group. IL-6 and TNF-alpha concentrations were related to fat mass distribution in the NWO women.Conclusions: The proinflammatory cytokines could be regarded as significant prognostic indicators of the risk of obesity, CVD, and the metabolic syndrome in NWO women.